Publications by authors named "Athena N Nguyen"
Article Synopsis
- Early life adaptations in immune system function are crucial for infant health, with newborns facing environmental challenges that test their immune response.
- Adenosine deaminases (ADAs), specifically ADA-1 and ADA-2, play important roles in immune modulation, and infants typically show lower ADA activity, resulting in higher levels of plasma adenosine and an anti-inflammatory bias.
- A study comparing plasma ADA activity in infants from Papua New Guinea to those from The Gambia found that PNG infants had lower ADA levels at birth but these levels increased and converged by the one-month mark, highlighting the importance of genetic and environmental factors in immune development.
Background: The long-term immunologic effects of antiretroviral therapy (ART) in children with perinatally-acquired HIV (PHIV) have not been fully elucidated. Here, we investigated how the timing of ART initiation affects the long-term immune profile of children living with PHIV by measuring immunomodulatory plasma cytokines, chemokines, and adenosine deaminases (ADAs).
Methods: 40 PHIV participants initiated ART during infancy.
Kinetic modeling of H2O2 dynamics in the mitochondria of HeLa cells.
PLoS Comput Biol
September 2020
Hydrogen peroxide (H2O2) promotes a range of phenotypes depending on its intracellular concentration and dosing kinetics, including cell death. While this qualitative relationship has been well established, the quantitative and mechanistic aspects of H2O2 signaling are still being elucidated. Mitochondria, a putative source of intracellular H2O2, have recently been demonstrated to be particularly vulnerable to localized H2O2 perturbations, eliciting a dramatic cell death response in comparison to similar cytosolic perturbations.
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