Accuracy and reproducibility of a cone beam CT-based virtual parenchymal perfusion algorithm in the prediction of SPECT/CT anatomical and volumetric results during the planification of radioembolization for HCC.

Objectives: To evaluate anatomical and volumetric predictability of a cone beam computed tomography (CBCT)-based virtual parenchymal perfusion (VPP) software for the single-photon-emission computed tomography (SPECT)/CT imaging results during the work-up for transarterial radioembolization (TARE) procedure in patients with hepatocellular carcinoma (HCC).

Methods: VPP was evaluated retrospectively on CBCT data of patients treated by TARE for HCC. Tc macroaggregated albumin particles (Tc-MAA) uptake territories on work-up SPECT/CT was used as ground truth for the evaluation.