Scalable Microreactor Concept for the Continuous Kolbe Electrolysis of Carboxylic Acids Using Aqueous Electrolyte.

The Kolbe electrolysis is a promising reaction to combine the usage of electrons as reagents and the application of renewable generated carboxylic acids as raw materials producing value added chemicals. Within this study, the electrolysis was conducted in a specially developed concept electrochemical microreactor and draws the particular attention to continuous operation and reuse of the aqueous electrolyte as well as of the dissolved unreacted feedstock. The electrolysis was conducted in alkaline aqueous solution using n-octanoic acid as model substance.

Leukocyte integrins: role in leukocyte recruitment and as therapeutic targets in inflammatory disease.

Infection or sterile inflammation triggers site-specific attraction of leukocytes. Leukocyte recruitment is a process comprising several steps orchestrated by adhesion molecules, chemokines, cytokines and endogenous regulatory molecules. Distinct adhesive interactions between endothelial cells and leukocytes and signaling mechanisms contribute to the temporal and spatial fine-tuning of the leukocyte adhesion cascade.