Effect of constant-current pallidal deep brain stimulation for primary dystonia on cognition, mood and quality of life: Results from a prospective pilot trial.

Objective: Knowledge on the effects of DBS on cognitive functions is limited and no data exists on the effects of constant-current DBS (CC-GPi-DBS), which appears to prevail over constant-voltage stimulation. Our aim was to prospectively assess the effect of Constant-Current-GPi-DBS, using an 8-contact lead, on cognition, mood and quality of life.

Patients And Methods: Ten patients aged 27-49 underwent prospective neuropsychological assessment using dedicated tests.

Constant-Current Deep Brain Stimulation of the Globus Pallidus Internus in the Treatment of Primary Dystonia by a Novel 8-Contact (Octrode) Lead.

Objective: To evaluate bilateral constant-current globus pallidus internus (GPi) deep brain stimulation using an 8-contact lead.

Methods: This prospective, open-label, single-center pilot study of 10 patients assessed the feasibility of delivering bilaterally constant-current GPi deep brain stimulation with a novel 8-channel lead to treat primary dystonia using standard scales as outcome measures.

Results: Patients included 4 men and 6 women with a mean age of 35.

Neuromyotonia in idiopathic hypoparathyroidism.

Alpha 62-year-old man was presented with bilateral cataract, proximal muscle weakness and difficulty in relaxing the hands after voluntary contraction. Idiopathic hypoparathyroidism was diagnosed. Electrophysiological study showed spontaneous motor unit action potentials, occurring and disappearing abruptly, as duplets, triplets and multiplets, with an intra-burst frequency of up to 100 Hz and some of them waning in amplitude, findings consistent with neuromyotonia.