Publications by authors named "Athanasios Tasis"
• Aging leads to chronic inflammation and immune dysfunction, heightening the risk of myeloid malignancies like MDS and CMML. • Both aging and MDS show alterations in monocyte subtypes and function. Aging boosts inflammatory genes upregulation, whereas MDS favors antigen presentation, reflecting distinct immune and disease-specific adaptations.
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- CD8+ T cells play a vital role in fighting cancer, but their functionality is compromised in higher-risk myelodysplastic neoplasms (HR-MDS) and acute myeloid leukemia (AML).
- An analysis of 104 pre-treatment bone marrow samples revealed that patients who did not respond to azacitidine therapy had higher levels of a specific CD8+ T cell subset (CD57+CXCR3+), which was linked to worse survival outcomes.
- The study also highlighted that successful treatment responses were associated with stronger IFN signaling, while non-responders showed increased TGF-β signaling, suggesting that combining TGF-β inhibitors with azacitidine could improve treatment in these cancer types.
Introduction: Immune checkpoint blockade (ICB) immunotherapy has revolutionized cancer treatment, demonstrating exceptional clinical responses in a wide range of cancers. Despite the success, a significant proportion of patients still fail to respond, highlighting the existence of unappreciated mechanisms of immunotherapy resistance. Delineating such mechanisms is paramount to minimize immunotherapy failures and optimize the clinical benefit.
View Article and Find Full Text PDFBrucellosis is a common zoonotic disease caused by intracellular pathogens of the genus . infects macrophages and evades clearance mechanisms, thus resulting in chronic parasitism. Herein, we studied the molecular changes that take place in human brucellosis both and RNA sequencing was performed in primary human macrophages (Mφ) and polymorphonuclear neutrophils (PMNs) infected with a clinical strain of spp.
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