Mechanistic study on the anti-proinflammatory activity of Kunitz type inhibitor from Caesalpinia decapetala seeds.

The study reports the biochemical characterization and mechanism of action of a novel 19.6 kDa protease inhibitor (PIs) isolated from the seeds of Caesalpinia decapetala belonging to the Fabaceae family. A systematic study was performed to ascertain the purity, specificity, biochemical and structural characterization, and its potential in curbing inflammation in vitro conditions.

Curcumin-sunflower protein nanoparticles-A potential antiinflammatory agent.

Curcumin is an antiinflammatory molecule, however, due to its lipophilic nature, has the limitation of very low aqueous solubility and degrades rapidly when dispersed in aqueous media. The potential of sunflower seed protein isolate (SFPI), one of the underutilized plant protein, as a drug carrier was studied by synthesizing SFPI nanoparticles (NPs) and encapsulating curcumin in NPs. Increase in solubility of encapsulated curcumin was observed with an encapsulation efficiency of 83%.