Systemic toxicity following cancer chemotherapy is an important concern. Targeted drug delivery systems could reduce the toxicity of anticancer drugs. Vitamins have been considered as targeting moieties in novel cancer treatment strategies.
View Article and Find Full Text PDFBiotin molecules could be used as suitable targeting moieties in targeted drug delivery systems against tumors. To develop a biotin targeted drug delivery system, we employed human serum albumin (HSA) as a carrier. Methotrexate (MTX) molecules were conjugated to HSA.
View Article and Find Full Text PDFActive targeting could increase the efficacy of anticancer drugs. Methotrexate-human serum albumin (MTX-HSA) conjugates, functionalized by luteinizing hormone-releasing hormone (LHRH) as targeting moieties, with the aim of specifically targeting the cancer cells, were prepared. Owing to the high expression of LHRH receptors in many cancer cells as compared to normal cells, LHRH was used as the targeting ligand in this study.
View Article and Find Full Text PDFPurpose: The purpose of this study was to compare microshear bond strength of three different luting resins using a new microshear method closely simulating clinical condition.
Methods: Thirty 1-mm-thick slices of intact human first molars and thirty 0.8-mm-diameter feldspathic porcelain rods were etched by 37% phosphoric acid for enamels and 9.