Rho kinase, a potential target in the treatment of metabolic syndrome.

Introduction: Metabolic syndrome is a health issue which is recognized due to its insulin resistance, central obesity, dyslipidemia, and hypertension. Since the Rho family of GTPases are involved in several cellular mechanisms, it is believed they might be involved in different aspects of metabolic syndrome. We conducted a search of some databases such as PubMed for articles and reviews published between 1997 and 2017, with different keywords including "metabolic syndrome", "rho kinase", "dyslipidemia", "hypertension", "central obesity", "insulin resistance" and the connectors AND or OR.