Publications by authors named "Atefeh Hajiagha Bozorgi"
The outbreak of the second severe acute respiratory syndrome coronavirus (SARS-CoV-2) known as COVID-19 has caused global concern. No effective vaccine or treatment to control the virus has been approved yet. Social distancing and precautionary protocols are still the only way to prevent person-to-person transmission.
View Article and Find Full Text PDFObjective: With respect to the reported promising results of cyclic peptide CGPRPPC in early detection of thrombotic lesions, we developed a practical approach for technetium-99m labeling of this peptide using the Glycine-Alanine-Glycine-Glycine (GAGG) sequence as a chelating moiety.
Materials And Methods: The peptide conjugated to GAGG was prepared using the solid-phase method. The optimization of radiolabeling conditions was performed on the basis of such variables as incubation time, reaction temperature, pH, and concentration of peptide and stannous chloride.
Article Synopsis
- Many patients globally experience cardiovascular issues linked to thrombosis, highlighting the need for an effective molecular imaging technique for early detection.
- Fibrin, a key component of blood clots and absent in circulation, serves as a specific target for imaging thrombi, and the study compares linear and cyclic fibrin-binding peptides for their effectiveness.
- Findings show that the cyclic peptide has high stability in human plasma, fast blood clearance, and allows for the imaging of thrombosis in live rabbit models, making it a promising candidate for improving molecular imaging in clinical settings.