The emerging role of the microglia triggering receptor expressed on myeloid cells (TREM) 2 in multiple sclerosis.

Background: The chronic inflammatory condition known as multiple sclerosis (MS) causes inflammation and demyelination in the central nervous system (CNS). The activation of multiple cell types, including the CNS's resident immune cells called microglia, is a component of the immunological response in MS. Recently, the triggering receptor expressed on myeloid cells (TREM) family has emerged as a crucial player in modulating microglial function and subsequent neuroinflammation.

Effect of forced treadmill exercise and blocking of opioid receptors with naloxone on memory in male rats.

Background: The forced treadmill running can influence the opioid contents of the brain, through both effects of exercise and the effects of stress caused by coercion. Since opioids can cause negative effects on brain functions, this study aimed to evaluate the effect of forced treadmill exercise and blocking of opioid receptors with naloxone on memory in male rats.

Materials And Methods: Experimental groups were the control, the exercise, the naloxone, and the naloxone exercise.