Publications by authors named "Atefeh Ahmadzadeh"
Background: Despite successful clinical outcomes of biologic medications in patients with chronic rheumatic diseases, some considerable adverse effects such as infections remain a major concern. Possibility of tuberculosis (TB) reactivation over treatment with anti-tumor necrotizing factor (TNF) alpha agents has necessitated a screening test before initiation of treatment. However, screening over the course of treatment is not recommended in those patients with negative baseline screening tests.
View Article and Find Full Text PDFArticle Synopsis
- Idiopathic hypogonadotropic hypogonadism (IHH) is a condition caused by low levels of gonadotropin-releasing hormone (GnRH), leading to issues with sexual maturation, with Kallmann syndrome being a notable disorder associated with it.
- Kallmann syndrome includes GnRH deficiency and often features anosmia (loss of smell), and is primarily inherited in an X-linked recessive pattern, although other inheritance modes are found.
- This study examined the KAL1 gene mutations in twenty patients, identifying specific deletions in exons and a significant hemizygous mutation in exon 12 in some patients, aiding potential early diagnosis and treatment of Kallmann syndrome.