Publications by authors named "Atef El-Hela"

Background and Objectives: Fibrotic lung disease is one of the main complications of many medical conditions. Therefore, the use of anti-fibrotic agents may provide a chance to prevent, or at least modify, such complication. The aim of this study was to evaluate the protective pulmonary anti-fibrotic and anti-inflammatory effects of Dinebra retroflexa.

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Background: (L.f.) Baker (Hyacinthaceae) is a perennial bulbous medicinal plant that is currently at risk of extinction.

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Background: Medicinal plants are recognized to have a wide range of important biological activities, Spergula fallax L. is a well-known plant while phytochemical and biological activities screening of the species are rare.

Objective: This study aims to evaluate the antioxidant, anticáncer, antimicrobial, and antiviral activities of the methanol extract (ME) of the aerial parts of Spergula fallax L.

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Purpose: Numerous applications of compatible salts (osmolytes) as ectoine in food and pharmaceutical industries have been intensively increased nowadays. Decreasing the cost of industrial production of ectoine using low-cost cultivation media and improving the yield through modeling procedures are the main scopes of the present study.

Methods: Three statistical design experiments have been successfully applied for screening the parameters affecting the production process, studying the relations among parameters and optimizing the production using response surface methodology.

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Six metabolites () were isolated from the aerial parts of Fresen. (Plantaginaceae) growing in Saint Catherine region in Egypt; two of them ( and ) are here reported to be newly identified naturally occurring iridoids. The isolated metabolites were identified as 6--foliamenthoyl-(6'--cinnamoyl)-antirrhinoside (), 6'--cinnamoyl-antirrhinoside (), the iridoid dimer, pubescensoside (), antirrhinoside (), 10-hydroxy-antirrhinoside (), and the flavonoid, diosmin ().

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Family Cupressaceae is the largest coniferous plant family. Essential oils of many species belonging to family Cupressaceae are known to have several biological activities specially antimicrobial activity. The essential oils from aerial parts of Torr.

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Bioassay guided fractionation and chemical investigation of the ethanolic extract of the aerial parts of Laxm. (Sapindaceae), resulted in the isolation and identification of three new triterpenoid saponins named Paniculatosoid A-C, along with eleven known compounds. The structures of the isolated compounds were elucidated using 1D and 2D NMR experiments, HRESIMS, and comparison with literature data.

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Bioassay guided fractionation of the ethanolic extract of Asphodelus microcarpus Salzm. et Viv. (Xanthorrhoeaceae or Asphodelaceae) resulted in isolation of five compounds identified as asphodosides A-E (1-5).

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Phytochemical study of the ethanolic extract of Salzm. et Viv. (Asphodelaceae) resulted in the isolation of two new compounds, methyl-1,4,5-trihydroxy-7-methyl-9,10-dioxo-9,10-dihydroanthracene-2-carboxylate (), and (1) 3,10-dimethoxy-5-methyl-1-1,4-epoxybenzo[]isochromene () as well as three known compounds; 3,4-dihydroxy-methyl benzoate (), 3,4-dihydroxybenzoic acid (), and 6-methoxychrysophanol ().

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Phenol compounds are naturally occurring biologically active compounds existing in all plants had received major medical concern so development in research focused on their extraction, identification and quantification have occurred over the last 25 years; they constitute an important source of antioxidants and were used to help human body to reduce oxidative damage. Mosquitos-borne diseases constitute one of the major health problems worldwide. Control strategies involving pinpointing natural ecological friend, cheap and safe mosquitocides, mainly larvicides to stop their life cycle.

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Four new (-) and two known ( and ) α-pyrone derivatives have been isolated from , an endophytic fungus from , leaves. The isolated compounds were chemically identified to be 5-butyl-4-methoxy-6-methyl-2-pyran-2-one (), 5-butyl-6-(hydroxymethyl)-4-methoxy-2-pyran-2-one (), 5-(1-hydroxybutyl)-4-methoxy-6-methyl-2-pyran-2-one (), 4-methoxy-6-methyl-5-(3-oxobutyl)-2-pyran-2-one (), 5-(2-hydroxyethyl)-4-methoxy-6-methyl-2-pyran-2-one (), and 5-[(2)-but-2-en-1-yl]-4-methoxy-6-methyl-2-pyran-2-one (). Compounds and showed moderate antileukemic activities against HL60 cells with IC values of 2.

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Nigrosphaerin A, a new isochromene derivative (), was isolated from the endophytic fungus and chemically identified as 3-(3,4-dihydroxyphenyl)-4,6,8-trihydroxy-1H-isochromen-1-one-6-O--d-glucopyranoside. In addition nineteen known compounds (-) were isolated from the same fungus and chemically identified. Compounds (-, , and -) were isolated for the first time from this fungus.

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Bioassay guided fractionation of the ethanolic extract of Asphodelus microcarpus Salzm.et Vivi (Asphodelaceae) resulted in the isolation of one new metabolite, 1,6-dimethoxy-3-methyl-2-naphthoic acid (1) as well as nine known compounds: asphodelin (2), chrysophanol (3), 8-methoxychrysophanol (4), emodin (5), 2-acetyl-1,8-dimethoxy-3-methylnaphthalene (6), 10-(chrysophanol-7'-yl)-10-hydroxychrysophanol-9-anthrone (7), aloesaponol-III-8-methyl ether (8), ramosin (9) and aestivin (10). The compounds were identified by 1D and 2D NMR and HRESIMS.

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Polyphenols constitute a distinct group of natural compounds of medicinal importance exhibiting wide range of physiological activities as antioxidant, immunestimulant, antitumor and antiparasitic. Yellow fever and dengue fever are mosquito-borne infectious diseases transmitted by Aedes aegyptii, the presence of yellow fever in Sudan and dengue fever in Saudi Arabia are threats to Egypt with the reemerging of Ae. aegyptii in Southern Egypt, larvae control is feasible than flying adults.

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Medicinal plants are the most potential resource of new therapeutic agents. They are diverse, largely productive, biologically active and chemically unique; among their constituents "polyphenol compounds group" one of the main determinant factors in evaluating the pharmacological potentials i.e.

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Many species belonging to Cucurbitaceae family have long been regarded as food, medicinal plants, or both. Preliminary phytochemical screening of Citrullus colocynthis L., Cucumis sativus L.

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From the leaves of Chamaecyparis obtusa several biflavones were isolated and identified, namely: sciadopitysin, ginkgetin, isoginkgetin, podocarpusflavone B, 7,7"-O-dimethylamentoflavone, bilobetin, podocarpusflavone A, and 7-O-methylamentoflavone. The presence of amentoflavone and hinokiflavone was also confirmed. The composition of biflavones in other Chamaecyparis species--Ch.

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