Publications by authors named "Ateeq M Khaliq"
Although the spatial, cellular and molecular landscapes of resected pancreatic ductal adenocarcinoma (PDAC) are well documented, the characteristics of its metastatic ecology remain elusive. By applying spatially resolved transcriptomics to matched primary and metastatic PDAC samples, we discovered a conserved continuum of fibrotic, metabolic and immunosuppressive spatial ecotypes across anatomical regions. We observed spatial tumor microenvironment heterogeneity spanning beyond that previously appreciated in PDAC.
View Article and Find Full Text PDFArticle Synopsis
- Researchers identified 25 different cell states, focusing on those linked to aggressive disease and poor prognosis, including specific immune cells and cancer-associated fibroblasts (CAFs).
- The findings highlight the relationship between the composition of the TME, stemness in malignant cells and CAFs, and patient survival, suggesting potential for improved risk assessment and personalized treatment strategies.
Background: Colorectal cancer (CRC) consensus molecular subtypes (CMS) have different immunological, stromal cell, and clinicopathological characteristics. Single-cell characterization of CMS subtype tumor microenvironments is required to elucidate mechanisms of tumor and stroma cell contributions to pathogenesis which may advance subtype-specific therapeutic development. We interrogate racially diverse human CRC samples and analyze multiple independent external cohorts for a total of 487,829 single cells enabling high-resolution depiction of the cellular diversity and heterogeneity within the tumor and microenvironmental cells.
View Article and Find Full Text PDF