Publications by authors named "Ataulina A"
Objective: The aim of this study is to elaborate a valid and reliable Russian version of the ALSFRS-R.
Methods: Russian adaptation of the ALSFRS-R was applied twice in 50 ALS patients followed by the test-retest analysis with a 7-day interval between applications and internal consistency analysis.
Results: Test-retest analysis showed very strong correlation for all of the ALSFRS-R variables.
Article Synopsis
- ALS is a life-threatening neurodegenerative disease affecting 1 in 350 individuals, and there is a significant need for treatments that modify the disease's progression.
- A large genome-wide association study (GWAS) identified 15 genetic risk loci associated with ALS by analyzing data from nearly 30,000 ALS patients compared to over 122,000 controls.
- The study highlights genetic connections to other neurodegenerative traits and concludes that high cholesterol levels may play a causal role in ALS, emphasizing disturbances in cellular transport and autophagy as key factors in the disease’s development in glutamatergic neurons.
Dysphagia and progressive swallowing problems due to motoneuron death is one of amyotrophic lateral sclerosis (ALS) symptoms. Malnutrition and body weight loss result in immunological disturbances, fatigability and increase risk of secondary complications in ALS patients, percutaneous endoscopic gastrostomy tube (PEG) placement representing a well-recognized method for malnutrition correction and potentially increasing life expectancy. However, despite nutritional correction, occasional rapid neurological deterioration may develop after PEG placement.
View Article and Find Full Text PDFThe epidemiology of amyotrophic lateral sclerosis in Moscow (Russia).
Amyotroph Lateral Scler Frontotemporal Degener
August 2020
: To estimate the incidence of amyotrophic lateral sclerosis (ALS) in Moscow by investigating multiple sources of cases. Incidence rates from previous Russian studies ranged from 0.3 to 0.
View Article and Find Full Text PDF[The Edinburgh Cognitive and Behavioral ALS Screen (ECAS): a Russian version.].
Zh Nevrol Psikhiatr Im S S Korsakova
May 2019
Aim: To translate into Russian and adapt the Edinburgh Cognitive and Behavioral ALS Screen (ECAS) for patients with amyotrophic lateral sclerosis (ALS).
Material And Methods: Medical care for ALS patients requires participation of a multidisciplinary team. More than one third of patients with ALS suffer from cognitive and behavioral disturbances, and it influences decisions of the team, patients and family.