Effects of post-polymerization on stainability and surface roughness of 3D printed composite resin.

Statement Of Problem: Although the post-polymerization is a necessary step to attain the final properties and color of the 3-dimensionally (3D) printed composite resins, research on its effects on color change and surface roughness is lacking.

Purpose: The purpose of this in vitro study was to evaluate the effect of post-polymerization time and additional placement in boiling water on the color change and surface roughness of 3D printed composite resins after exposure to coffee for 30 days.

Material And Methods: Sixty disk-shaped specimens (Ø10×2 mm) were 3D printed with composite resin (Crowntec).

Investigating the complex cortical dynamics of an advanced concentrative absorption meditation called jhanas (ACAM-J): a geometric eigenmode analysis.

Advanced meditation has been associated with long- and short-term psychological changes such as bliss, profound insight, and transformation of well-being. However, most advanced meditation neuroimaging analyses have implemented primarily spatially-localized approaches, focusing on discrete regional changes in activity rather than distributed dynamics. The present study uses a geometric eigenmode decomposition of ultrahigh field-strength 7T functional magnetic resonance imaging (fMRI) data from an intensely sampled case study to investigate the complex, distributed cortical dynamics associated with advanced concentrative absorption meditation.

Effects of post-curing conditions on degree of conversion, microhardness, and stainability of 3D printed permanent resins.

Background: The aim of this in-vitro study is to investigate the effect of post-curing time and units on the degree of conversion (DC), microhardness (VHN) and staining susceptibility (∆E) of two 3D printed permanent resins (Crowntec (SCT), Varseosmile Crown (VSP)).

Methods: A total of 180 disc-shaped samples (10*10*2 mm), 60 for each experiment, from the tested materials (30 SCT, 30 VSP) were printed on 3D printer. Half of the samples were post-cured in LC-3DPrint Box and the other half in Phrozen Cure V2 and were divided into 3 subgroups according to post-curing time of 5, 10 and 30 min (n = 5).

Connectome harmonic decomposition tracks the presence of disconnected consciousness during ketamine-induced unresponsiveness.

Background: Ketamine, in doses suitable to induce anaesthesia in humans, gives rise to a unique state of unresponsiveness accompanied by vivid experiences and sensations, making it possible to disentangle the correlated but distinct concepts of conscious awareness and behavioural responsiveness. This distinction is often overlooked in the study of consciousness.

Methods: The mathematical framework of connectome harmonic decomposition (CHD) was used to view functional magnetic resonance imaging (fMRI) signals during ketamine-induced unresponsiveness as distributed patterns across spatial scales.

Multifunctional theranostic glyconanoprobes for synergistic eradication of breast cancer.

Theranostic agents hold great promise for personalized medicine by combining diagnostic and therapeutic functions. Herein, two novel multifunctional theranostic glyconanoprobes targeting breast cancer were engineered for synergistic dual chemo-gene therapy and triple chemo-gene-photothermal therapy. Upconversion nanoparticles (UCNPs) were prepared and coated with a Dox-loaded glycopeptide polymer (P-Dox) to form UCNP@P-Dox for improving stability.

Effect of bleaching and repolishing on whiteness change and staining susceptibility of resin-based materials.

Background: The aim of this study was to investigate the effects of different types of bleaching methods and repolishing on the whiteness index and staining susceptibility of additive and subtractive production resin-based materials and direct composite resins.

Methods: In this study, a total of 96 samples (8*8*2m) were prepared using a nanohybrid composite resin (Neo Spectra-ST (NS)), a subtractive-manufactured nanoceramic resin (Cerasmart270 (CS)), and an additive-manufactured permanent resin (Saremco print Crowntec (CT)). The samples were randomly divided into four treatment groups: control (distilled water, 14 days), in-office bleaching (Opalescence Boost-40% HP, 3*20min), at-home bleaching (Opalescence PF-16% CP, 6 h, 14 days), and toothpaste group (Opalescence Whitening, 2*5min, 14 days) (n:8).

The Effect of Gastric Acid and Material Type on the Surface Roughness of Additive and Subtractive Manufacturing Resins.

Purpose: The aim of this study is to examine the effect of gastric acid on the surface roughness of additive and subtractive manufacturing resin.

Materials And Methods: In this study, two subtractive manufacturing CAD-CAM resin nanoceramic (CerasmartTM270 (CS), LavaTM Ultimate (LU)) and two additive manufacturing 3D printing permanent resin (VarseoSmile Crownplus (VSP), Crowntec (CT)) was used. CS and LU samples were turned into 10 mm diameter cylinders with a scraper and cut into 2 mm slices on the cutting device.

Recurrent depression predicts high leptin concentrations in patients with coronary artery disease over an 18-months follow-up period: Findings from the prospective multicenter randomized controlled SPIRR-CAD Trial.

Background: Leptin, an adipokine suspected to play a role in coronary artery disease (CAD), may also be associated with deteriorated mental health. We investigated the prospective impact of recurrent depressed mood (RDM) on heightened plasma leptin levels in CAD patients.

Methods: Derived from the randomized SPIRR-CAD trial, plasma leptin were measured by the Human Leptin DuoSet ELISA at baseline in 539 patients (including 115 (21.

Monomer Elution of Additive and Subtractive Manufactured Resins for Permanent Restorations.

Purpose: To evaluate the elution of residual monomers from resins used in additive and subtractive manufactured permanent restorations over a period of one month, using highperformance liquid chromatography (HPLC). Materials and Methods: Two additive manufacturing permanent crown resins (Crowntec, CT and VarseoSmile Crown Plus, VS) and a subtractive manufacturing resin nanoceramic (Cerasmart, CS) were used to fabricate 30 disc-shaped samples (10 × 2 mm) (n=10). The elution of bisphenol A ethoxylate dimethacrylate (BisEMA), urethane dimethacrylate (UDMA), and triethylene glycol dimethacrylate (TEGDMA) monomers was measured with HPLC at 1 day and 30 days after immersion.

LC-MS and GC-MS Analyses on Green Algae Penicillus Capitatus: Cytotoxic, Antimicrobial and Anticholinesterase Activity Screening Enhanced by Molecular Docking & Dynamics and ADME Studies.

In this comprehensive screening study, the chemical composition, and cytotoxic, antimicrobial, and anticholinergic activities of the green algae Penicillus capitatus, collected from Antalya-Türkiye, were determined as in vitro and in silico. GC-MS analysis of the hexane extract revealed a high content of fatty acids, with hexadecanoic acid constituting half of the total fatty acid content. LC-HRMS analysis of the DCM:MeOH extract identified ascorbic acid as the most abundant compound, followed by (-)-epigallocatechin and salicylic acid.

Time-resolved coupling between connectome harmonics and subjective experience under the psychedelic DMT.

Exploring the intricate relationship between brain's structure and function, and how this affects subjective experience is a fundamental pursuit in neuroscience. Psychedelic substances offer a unique insight into the influences of specific neurotransmitter systems on perception, cognition and consciousness. Specifically, their impact on brain function propagates across the structural connectome - a network of white matter pathways linking different regions.

The flattening of spacetime hierarchy of the -dimethyltryptamine brain state is characterized by harmonic decomposition of spacetime (HADES) framework.

The human brain is a complex system, whose activity exhibits flexible and continuous reorganization across space and time. The decomposition of whole-brain recordings into harmonic modes has revealed a repertoire of gradient-like activity patterns associated with distinct brain functions. However, the way these activity patterns are expressed over time with their changes in various brain states remains unclear.

Effect of repeated preheating on monomer elution from a bulk-fill composite resin.

Background: Due to incomplete polymerization of composite resin restorations, residual monomers adversely affect their mechanical properties and biocompatibility. Preheating of composite resins is advised to increase the degree of conversion and reduce monomer elution. This study aimed to analyze the effect of preheating and repeated preheating on the amount of monomer released from a bulk-fill composite resin.

Effects of three disinfection solutions on residual monomers released from resin nanoceramic CAD/CAM blocks.

The aim of this study was to evaluate the effects of three disinfection solutions on the amount of monomers released from resin nanoceramic CAD/CAM blocks using high performance liquid chromatography (HPLC). Forty resin nanoceramic CAD/CAM (Cerasmart, GC, Japan) samples (12x14 × 2 mm) were divided into four groups; each group was disinfected using one of four solutions (Group 1: no disinfectant; Group 2: 70 % ethanol; Group 3: 2 % glutaraldehyde; and Group 4: 1 % sodium hypochlorite) for 5 min. Analysis of residual monomers (UDMA and Bis-EMA) amounts was performed using an HPLC instrument (Dionex Ultimate 3000, Thermo Fisher Scientific).

Work Experience of Intensive Care Nurses during the Period of the Pandemic: A Qualitative Study.

This study was conducted to describe the working experiences, feelings, and thoughts of nurses working in the intensive care unit (ICU) during the COVID-19 pandemic from their perspective. Empirical phenomenological approach, one of the qualitative study methods, was used to obtain detailed descriptions of the experiences of nurses working in the ICU during the COVID-19 outbreak in providing patient care. The research design is an in-depth interview technique.

Hypertension in the first blood pressure reading and the risk of cardiovascular disease mortality in the general population: findings from the prospective KORA study.

Background: The risk of cardiovascular disease (CVD) mortality in individuals with an alerting reaction, assessed by hypertension in the first blood pressure (BP) reading but normal BP in further readings, remains unknown in the general population.

Methods And Results: In a sample of 11 146 adults (51.5% men and 48.

The effects of prophylactic tadalafil use on VEGF expression in the rabbit model of steroid-induced femoral head avascular necrosis.

Objective: The purpose of this study was to examine the effect of prophylactic tadalafil use on a steroid-induced femoral head avascular necrosis model in terms of microscopic, imaging, and molecular biological changes.

Methods: Twenty-four New Zealand rabbits were divided into 3 equal groups. Eight rabbits were designated as the control group and did not receive treatment.

Success rate of rapid DNA technology in kinship analysis for forensic purpose.

Reducing the time required for DNA analysis in forensic genetics can yield significant benefits, both in determining genealogical relationships for legal proceedings and in criminal cases. Swift identification of individuals plays a pivotal role in solving crimes and apprehending perpetrators. Additionally, in situations like mass disasters, prompt victim identification holds utmost importance.

Emodin and aloe-emodin, two potential molecules in regulating cell migration of skin cells through the MAP kinase pathway and affecting Caenorhabditis elegans thermotolerance.

Background: Emodin and aloe-emodin are two anthraquinones having positive effects in wound healing. However, their mechanism of action of wound healing is not fully understood. The MAP kinase family, which plays an active role in wound healing, is a well-characterized large family of serine/threonine kinases and regulates processes such as proliferation, oncogenesis, differentiation, and inflammation in the cell.

Covid-19 pandemic induced traumatizing medical job contents and mental health distortions of physicians working in private practices and in hospitals.

The Covid-19 pandemic during its early phases posed significant psychological threats particularly for medical frontline personal. It is unclear whether the medical workforce with the passage of time has adapted to these threats or have generalized to wider medical settings. An online survey was conducted reaching 1476 physicians in Germany with valid data from 1327 participants.

Design, synthesis and biological evaluation of Nucleosidic CD99 inhibitors that selectively reduce Ewing sarcoma viability.

Ewing Sarcoma (ES) is a cancer of bone and soft tissues affecting mostly children and young adults. Aggressive progression and poor prognosis of this malignancy call for novel and targeted treatments. CD99 is a transmembrane protein that is abundantly expressed on ES cells and is a diagnostic marker for the disease.

Psychometric Properties of the Turkish version of the Child and Adolescent Behavior Inventory Sluggish Cognitive Tempo Scale (CABI-SCT) in Children and Adolescents.

Sluggish cognitive tempo (SCT) (cognitive disengagement syndrome) (CDS) describes a cluster of symptoms including slowness, lethargy, and daydreaming. This study aims to evaluate the psychometric properties of the Turkish version of the Child and Adolescent Behavior Inventory (CABI-SCT) scale and its relationship to other psychological difficulties. A total of 328 children and adolescents aged between 6-18 years were included in the study.

Distributed harmonic patterns of structure-function dependence orchestrate human consciousness.

A central question in neuroscience is how consciousness arises from the dynamic interplay of brain structure and function. Here we decompose functional MRI signals from pathological and pharmacologically-induced perturbations of consciousness into distributed patterns of structure-function dependence across scales: the harmonic modes of the human structural connectome. We show that structure-function coupling is a generalisable indicator of consciousness that is under bi-directional neuromodulatory control.

DNA recovery and human identification from semen stains washed at different temperatures.

One of the most important pieces of evidence to find the suspect of a sexual assault are semen stains. It has been observed that suspects do not use condoms in many cases and transfer seminal fluids over the body of the victim, to their clothes, to bed linen, or to other objects in the environment. However, in many cases, it has been seen that the suspects or the victims tend to clean their bodies and clothes because of psychological conditions such as fear, panic, and anxiety.