Nanoparticle-Based Drug Delivery for Vascular Applications.

Nanoparticle (NP)-based drug delivery systems have received widespread attention due to the excellent physicochemical properties of nanomaterials. Different types of NPs such as lipid NPs, poly(lactic-co-glycolic) acid (PLGA) NPs, inorganic NPs (e.g.

First report of acifer group of the subgenus Tripodura Townes (Diptera: Chironomidae: Polypedilum) from India, with a new species and updated world checklist.

A new species of the acifer group of the subgenus Tripodura and genus Polypedilum Kieffer is described on the basis of adult male. The acifer species group is recorded firstly from India. The molecular barcoding of the new species is provided.

Chitosan-2D Nanomaterial-Based Scaffolds for Biomedical Applications.

Chitosan (CS) and two-dimensional nanomaterial (2D nanomaterials)-based scaffolds have received widespread attention in recent times in biomedical applications due to their excellent synergistic potential. CS has garnered much attention as a biomedical scaffold material either alone or in combination with some other material due to its favorable physiochemical properties. The emerging 2D nanomaterials, such as black phosphorus (BP), molybdenum disulfide (MoS), etc.

A new species of Thinophilus Wahlberg (Diptera: Dolichopodidae: Hydrophorinae) from coastal India with re-description of Thinophilus tesselatus Becker (Diptera: Dolichopodidae: Hydrophorinae).

A new peculiar species of marine dolichopodid fly from West Bengal, India is described: Thinophilus maritimus Mukherjee & Pramanik sp. nov. COI barcodes of the new species were compared to other available Thinophilus sequences.

Characterization of complete mitochondrial genome of three Horse flies of the genus Tabanus (Diptera: Tabanidae): comparative analysis.

Background: Tabanidae (Horse-Flies or Deer-Flies) are one of the most economically important as well as medically significant haematophagous insect family within the order Diptera. Members of this group are also responsible for the mortality of substantial number of live-stock every year. Due to their pathogen transmission potential and vector competencies makes them an important insect group to study.

Friends against the Foe: Synergistic Photothermal and Photodynamic Therapy against Bacterial Infections.

Multidrug-resistant (MDR) bacteria are rapidly emerging, coupled with the failure of current antibiotic therapy; thus, new alternatives for effectively treating infections caused by MDR bacteria are required. Hyperthermia-mediated photothermal therapy (PTT) and reactive oxygen species (ROS)-mediated photodynamic therapy (PDT) have attracted extensive attention as antibacterial therapies owing to advantages such as low invasiveness, low toxicity, and low likelihood of causing bacterial resistance. However, both strategies have notable drawbacks, including the high temperature requirements of PTT and the weak ability of PDT-derived ROS to penetrate target cells.

A checklist of black flies (Diptera, Simuliidae) from India.

An updated checklist of the family Simuliidae from India is presented. A total of 79 species of belonging to eight different subgenera are listed. Eleven species that were not reported in the previous checklist are added here.

Photo-Stimuli-Responsive CuS Nanomaterials as Cutting-Edge Platform Materials for Antibacterial Applications.

Photo-stimuli-responsive therapeutic nanomaterials have gained widespread attention as frontline materials for biomedical applications. The photoactivation strategies are classified as single-modality (based on either reactive oxygen species (ROS)-based photodynamic therapy (PDT), hyperthermia-based photothermal therapy (PTT)), or dual-modality (which combines PDT and PTT). Due to its minimal invasiveness, phototherapy has been extensively applied as an efficient therapeutic platform for many diseases, including skin cancers.

A Nanocomposite with Extracellular Vesicles from as a Bioinspired Nanoantibiotic Targeting .

The utilization of biomimetic materials that merge functional nanoparticles (NPs) with a cell-derived nanosized membrane is a state-of-the-art approach to harnessing cellular properties for biomedical applications. However, the development of biocompatible and species-selective biomimetic agents against hazardous pathogens threatening human health is still in its early stages. Herein, we report the synthesis and functional analysis of a novel nanoplatform in which a PEGylated MoS-ZnO (MZ) nanocomposite was cloaked with a generally regarded as safe (GRAS)-grade -derived extracellular vesicle (LPEV) for MZ-LPEV nanocomposite and evaluated its activity against .

Bioconjugated Thymol-Zinc Oxide Nanocomposite as a Selective and Biocompatible Antibacterial Agent against Species.

Owing to the rapid spread of antibiotic resistance among species, effective and low-risk alternatives to antibiotics are being actively searched. Thymol (THO), the most abundant component of the oil extracted from thyme, can be considered as a natural antibacterial alternative. However, the low antibacterial activity and non-selectivity of THO limit its usage as a universal anti- agent.

A MoS based silver-doped ZnO nanocomposite and its antibacterial activity against β-lactamase expressing .

Multidrug-resistant (MDR) Gram-negative bacteria including are increasingly resistant to current antibiotics. Among the strategies implemented to eradicate such MDR pathogens, approaches based on two-dimensional (2D) nanomaterials have received considerable attention. In particular, the excellent physicochemical properties of 2D molybdenum disulfide (MoS) nanosheets, including a high surface area, good conductivity, and good surface retention, are advantageous for their use as bactericidal agents.

Bovine Serum Albumin-Immobilized Black Phosphorus-Based γ-FeO Nanocomposites: A Promising Biocompatible Nanoplatform.

The interactions between proteins and nanoparticles need to be fully characterized as the immobilization of proteins onto various nanoplatforms in the physiological system often results in the change of surface of the protein molecules to avoid any detrimental issues related to their biomedical applications. Hence, in this article, the successful low-temperature synthesis of a BP-based γ-FeO (IB) nanocomposite and its interactive behavior with bovine serum albumin (BSA)-a molecule with chemical similarity and high sequence identity to human serum albumin-are described. To confirm the formation of γ-FeO and the IB nanocomposite, X-ray diffraction, transmission electron microscopy, and X-ray photoelectron spectroscopy analyses of the materials were performed.

A New Surface Charge Neutralizing Nano-Adjuvant to Potentiate Polymyxins in Killing Mcr-1 Mediated Drug-Resistant .

Resistance to polymyxins when treating multidrug-resistant (MDR) Gram-negative bacterial infections limit therapeutic options. Here, we report the synthesis of a nickel (Ni) doped Zinc oxide (NZO) combined with black phosphorus (BP) (NZB) nanocomposite and its synergistic action with polymyxin B (PolB) against polymyxin-resistant harboring mobilized colistin resistance () gene. NZB and PolB combination therapy expressed a specific and strong synergy against Mcr-1 expressing cells.

Au-ZnO Conjugated Black Phosphorus as a Near-Infrared Light-Triggering and Recurrence-Suppressing Nanoantibiotic Platform against .

Antibiotic therapy is the gold standard for bacterial infections treatment. However, the rapid increase in multidrug-resistant (MDR) bacterial infections and its recent use for secondary bacterial infections in many COVID-19 patients has considerably weakened its treatment efficacy. These shortcomings motivated researchers to develop new antibacterial materials, such as nanoparticle-based antibacterial platform with the ability to increase the chances of killing MDR strains and prevent their drug resistance.

A New Nano-Platform of Erythromycin Combined with Ag Nano-Particle ZnO Nano-Structure against Methicillin-Resistant .

Nano-particles have been combined with antibiotics in recent studies to overcome multidrug-resistant bacteria. Here, we synthesized a nano-material in which Ag nano-particles were assembled with a ZnO nano-structure to form an Ag-ZnO (AZO) nano-composite at low temperature. This material was combined with erythromycin (Ery), an antibiotic effective towards gram-positive bacteria, using three different approaches (AZO + Ery (AZE) [centrifuged (AZE1), used separately after 1-h gap (AZE2), without centrifugation (AZE3)]) to prepare a nano-antibiotic against clinical isolates of methicillin-resistant (MRSA).

Recent Advances in Nanomaterial-Based Wound-Healing Therapeutics.

Nanomaterial-based wound healing has tremendous potential for treating and preventing wound infections with its multiple benefits compared with traditional treatment approaches. In this regard, the physiochemical properties of nanomaterials enable researchers to conduct extensive studies on wound-healing applications. Nonetheless, issues concerning the use of nanomaterials in accelerating the efficacy of existing medical treatments remain unresolved.

A nontoxic biocompatible nanocomposite comprising black phosphorus with Au-γ-FeO nanoparticles.

Black phosphorus (BP) has emerged as the latest 2D material within the post-graphene scenario, which can be used for various biomedical applications. In this study, we reported a promising nanocomposite material, which could be assembled with Au nanoparticles and γ-FeO nanoparticles on BP nanosheets (AIB), and studied its biocompatibility that promises to be useful for various biomedical applications. The synthesis of the Au-γ-FeO nanomaterial was attained through low-temperature solution synthesis and the exfoliation of BP nanosheets was performed through a liquid ultrasonication process.

Easy One-Pot Low-Temperature Synthesized Ag-ZnO Nanoparticles and Their Activity Against Clinical Isolates of Methicillin-Resistant .

Antimicrobial resistance (AMR) is widely acknowledged as a global health problem, yet the available solutions to this problem are limited. Nanomaterials can be used as potential nanoweapons to fight against this problem. In this study, we report an easy one-pot low-temperature synthesis of Ag-ZnO nanoparticles (AZO NPs) and their targeted antibacterial activity against methicillin-resistant (MRSA) strains.

Antibacterial potential of Ni-doped zinc oxide nanostructure: comparatively more effective against Gram-negative bacteria including multi-drug resistant strains.

Infections by multidrug-resistant (MDR) bacteria are one of the most threatening concerns for public health. For this purpose, nanomaterials have emerged with great potential for antibacterial activity. In this paper, we report the synthesis of new Ni-doped zinc oxide (Ni-ZnO or NZO) nanostructures as targeted antibacterial agents for Gram-negative bacteria.

Black phosphorus nanomaterials as multi-potent and emerging platforms against bacterial infections.

Black phosphorus (BP) has attracted research interest due to its excellent physiochemical properties in various biomedical applications. However, challenges remain of establishing BP as a practical nanomaterial platform against bacterial infections caused by hard-to-treat pathogens. This review highlights the novel approaches for functional properties and advantages of BP over currently available two-dimensional nanomaterials for antibacterial activity.

Nanomaterials as Delivery Vehicles and Components of New Strategies to Combat Bacterial Infections: Advantages and Limitations.

Life-threatening bacterial infections have been well-controlled by antibiotic therapies and this approach has greatly improved the health and lifespan of human beings. However, the rapid and worldwide emergence of multidrug resistant (MDR) bacteria has forced researchers to find alternative treatments for MDR infections as MDR bacteria can sometimes resist all the present day antibiotic therapies. In this respect, nanomaterials have emerged as innovative antimicrobial agents that can be a potential solution against MDR bacteria.

Anti-biofilm activity and food packaging application of room temperature solution process based polyethylene glycol capped Ag-ZnO-graphene nanocomposite.

Present work reports on synthesis and anti-biofilm activity as well as food packaging application of Ag-ZnO-reduce graphene oxide (rGO)-polyethylene glycol (PEG) (AZGP) nanocomposites via adopting room temperature solution process by varying silver nitrate content (up to 0.1 M) with fixed content of graphene oxide and PEG used in the precursors. Presence of Ag and ZnO nanoparticles (NPs) distributed uniformly over rGO nanosheets has been confirmed by X-ray diffraction and transmission electron microscopic analyses whereas FTIR, Raman, UV-Visible and X-ray photoelectron spectral studies have been performed to confirm the existence of chemical interaction/complexation that happened between the available oxygen functionalities of rGO and PEG with the inorganic moieties (Ag-ZnO/Zn) of AZGP samples.

Scanning electron microscopic studies on antenna of Hemipyrellia ligurriens (Wiedemann, 1830) (Diptera: Calliphoridae)-A blow fly species of forensic importance.

Blow flies (Diptera: Calliphoridae) are one of the foremost organisms amongst forensic insects to colonize corpses shortly after death, thus are of immense importance in the domain of forensic entomology. The blow fly Hemipyrellia ligurriens (Wiedemann, 1830) (Diptera: Calliphoridae) is considered as a forensically important fly species globally and is also known for its medical and veterinary importance. In the present study, we report for the first time scanning electron microscopic studies on the morphology of sensilla of antenna of adult male and female of H.