Comparative Study of Adalimumab, Infliximab and Certolizumab Pegol in the Treatment of Cystoid Macular Edema Due to Behçet's Disease.

The leading cause of blindness due to non-infectious uveitis is cystoid macular edema (CME). Behçet's disease (BD) is one of the most commonly conditions related to CME. To compare the effectiveness and safety of adalimumab (ADA), infliximab (IFX) and certolizumab (CZP) in refractory CME due to BD.

Comparative Study of Infliximab Versus Adalimumab in Refractory Uveitis due to Behçet's Disease: National Multicenter Study of 177 Cases.

Objective: To compare the efficacy of infliximab (IFX) versus adalimumab (ADA) as a first-line biologic drug over 1 year of treatment in a large series of patients with refractory uveitis due to Behçet's disease (BD).

Methods: We conducted an open-label multicenter study of IFX versus ADA for BD-related uveitis refractory to conventional nonbiologic treatment. IFX or ADA was chosen as the first-line biologic agent based on physician and patient agreement.

[Bisphosphonate-related osteonecrosis of the jaw].

The bisphosphonates are stable inorganic pyrophosphate analogs that have demonstrated their efficacy in treatment of osteolytic lesions associated with bony metastases, and multiple myeloma, malignant hypercalcemia, Paget's disease, and osteoporosis. Several publications within the last few years have suggested that osteonecrosis of the jaw is associated with bisphosphonate therapy. The diagnosis and management strategies of the patients with bisphosphonate-related osteonecrosis of the jaw is very difficult.

[Osteoporosis as the first manifestation of minor beta-thalassemia].

We present the case of a 48-year-old premenopausal woman with right lumbosciatalgia secondary to osteoporosic vertebral collapses. Two of her three offsprings, a 31-year-old man and a 16-year-old woman, had chronic dorsolumbalgia, the study of which suggested the diagnosis of minor beta-thalassemia. As opposed to thalassemic osteoarthropathy, frequently observed in the forms of "major" and "minor" beta-thalassemia, rheumatic manifestations have almost never been described in the "minor" forms.

HLA and Behçet's disease in northern Spain: their lack of correlation with arthritis pattern.

We have studied the characteristics of arthritis present in 32 patients with Behçet's disease (BD), and how this arthritis is related to the HLA markers class I. 84% of the patients presented arthritis, the most common being mono-arthritis as the initial presentation, and oligoarthritis in subsequent episodes. In 63% of the cases, the development was in episodes of acute/subacute arthritis.

[Epidemiological study of Reiter's syndrome in a health service area].

A higher incidence of Reiter's Syndrome (RS) is observed among young white men. We have conducted an epidemiological study of RS cases from our current health area and diagnosed in our hospital between 1975 and 1989. Twenty-four patients were included in this study, with a relation between men and women of 12:1 and an average age of 33.

[Sternoclavicular staphylococcal arthritis in non-immunodepressed patients. Study of 4 cases].

We report four patients (3 males and one female) suffering a sternoclavicular staphylococcal arthritis in whom risk factors such as parenteral drug addiction, alcoholism, diabetes, or immunosuppression were not observed. The etiopathogenesis, clinical picture, and diagnosis of this uncommon septic arthritis in reviewed.

[Reiter's syndrome. A study of 25 cases].

The laboratory, radiological and clinical features of 25 cases of Reiter's syndrome were studied. Most of the subjects were between the 2nd and 4th decade of life (p less than 0.05).

[Pachydermoperiostosis (primary hypertrophic osteoarthropathy)].

A case of pachydermaperiostosis in a 16 year old male is presented. The main clinical features were bilateral mechanical gonalgia, acropachy, bilateral palpebral ptosis and hyperhydrosis. The diagnosis was confirmed by X-ray, showing a wide, symmetric periostosis.

[Peripheral tuberculous arthritis in Galicia].

We have evaluated the cases of tuberculous arthritis in peripheral joints (TAPJ) that had been diagnosed in our unit during the last twelve years. The diagnosis was made by synovial biopsy in 26 of 33 cases, and by synovial fluid culture in the remaining 7. TAPJ accounted for 2.

[Multiple aneurysms and cerebral vasculitis in systemic lupus erythematosus].

A female in whom systemic lupus erythematosus had been diagnosed 5 years before suddenly developed headache and recurrent vomiting. Cranial computed tomography (CT) was consistent with subarachnoid hemorrhage, and cerebral arteriography disclosed cerebral aneurysms, multiple microaneurysms and cerebral vasculitis. After 7 days she developed left hemiparesis, and a cerebral infarct area was apparent in a new CT scan.