Evaluation Of Maternal And Fetal Findings In Patients With Pemphigoid Gestationis.

Objective: To evaluate the maternal and fetal outcomes of 12 pregnant women diagnosed with pemphigoid gestationis, in conjunction with a review of the literature.

Methods: A retrospective review was conducted on the medical records of 12 patients diagnosed with pemphigoid gestationis who presented  between January 2014 and January 2024.

Results: Twelve pregnant patients with pemphigoid gestationis were included in the study.

Systemic Factors Affecting Human Beta-Defensins in Oral Cavity.

Human beta-defensins are host defense peptides with broad antimicrobial and inflammatory functions. In the oral cavity, these peptides are produced mainly by the keratinocytes of the epithelium; however, fibroblasts, monocytes, and macrophages also contribute to oral human beta-defensin expressions. The resident and immune cells of the oral cavity come into contact with various microbe-associated molecular patterns continuously and simultaneously.

The role of spatial uncertainty in the context-specific proportion congruency effect.

The prime-probe version of the Stroop task has been predominantly used to demonstrate the context-specific proportion congruency (CSPC) effect. In this version, the location of the color is not known until its presentation, creating a spatial uncertainty for the color dimension. We propose that spatial uncertainty plays an important role in observing the CSPC effect.

ZNF432 stimulates PARylation and inhibits DNA resection to balance PARPi sensitivity and resistance.

Zinc finger (ZNF) motifs are some of the most frequently occurring domains in the human genome. It was only recently that ZNF proteins emerged as key regulators of genome integrity in mammalian cells. In this study, we report a new role for the Krüppel-type ZNF-containing protein ZNF432 as a novel poly(ADP-ribose) (PAR) reader that regulates the DNA damage response.

The dynamic process of covalent and non-covalent PARylation in the maintenance of genome integrity: a focus on PARP inhibitors.

Poly(ADP-ribosylation) (PARylation) by poly(ADP-ribose) polymerases (PARPs) is a highly regulated process that consists of the covalent addition of polymers of ADP-ribose (PAR) through post-translational modifications of substrate proteins or non-covalent interactions with PAR via PAR binding domains and motifs, thereby reprogramming their functions. This modification is particularly known for its central role in the maintenance of genomic stability. However, how genomic integrity is controlled by an intricate interplay of covalent PARylation and non-covalent PAR binding remains largely unknown.

Cryogenic X-ray crystallographic studies of biomacromolecules at Turkish Light Source "".

X-ray crystallography is a robust and powerful structural biology technique that provides high-resolution atomic structures of biomacromolecules. Scientists use this technique to unravel mechanistic and structural details of biological macromolecules (e.g.

Rapid and efficient ambient temperature X-ray crystal structure determination at Turkish Light Source.

High-resolution biomacromolecular structure determination is essential to better understand protein function and dynamics. Serial crystallography is an emerging structural biology technique which has fundamental limitations due to either sample volume requirements or immediate access to the competitive X-ray beamtime. Obtaining a high volume of well-diffracting, sufficient-size crystals while mitigating radiation damage remains a critical bottleneck of serial crystallography.

Serum, saliva, and gingival tissue human β-defensin levels in relation to retinoic acid use.

Background: Retinoic acid is an active derivative of vitamin A and regulates the differentiation, proliferation, and antimicrobial peptide expression profiles of human cells. The aim of the present study was to analyze the effect of systemic retinoic acid use on serum, saliva, and gingival tissue levels of human β-defensin (hBD)-1, hBD-2, and hBD-3.

Methods: A total of 69 participants (34 systemic retinoic acid users and 35 healthy controls) were enrolled in this study.

Do arginine metabolites have a role in periodontitis due to smoking? A new perspective.

Objectives: Cigarette consumption is common around the world and besides its negative effects on health, and its effects on periodontitis draw attention. Arginine metabolites are involved in the pathogenesis of several systemic inflammatory diseases' including cardiovascular diseases. Our aim was to determine periodontitis and healthy individuals' arginine metabolites and IL-6 levels in saliva and serum and to evaluate those according to smoking status.

Functional Assessment of Coding and Regulatory Variants From the Locus.

The gene encodes an extracellular inhibitor of the Wnt pathway with an important role in bone tissue development, bone homeostasis, and different critical aspects of bone biology. Several BMD genome-wide association studies (GWASs) have consistently found association with SNPs in the genomic region. For these reasons, it is important to assess the functionality of coding and regulatory variants in the gene.

Does survival context enhance memory for source? A within-subjects comparison.

Nairne, Thompson, and Pandeirada [2007. Adaptive memory: Survival processing enhances retention. Journal of Experimental Psychology: Learning, Memory, and Cognition, 33, 263-273] demonstrated that processing words according to their relevance to a survival scenario enhanced their subsequent retrieval in recall and recognition tasks compared to a variety of control scenarios.

Ultrasonographic imaging of the effects of continuous, pulsed or sham ultrasound treatments on carpal tunnel syndrome: A randomized controlled study.

Background: Clinical and electrophysiological effects of therapeutic ultrasound (US) were researched in many studies on patients with CTS with conflicting results.

Objective: To assess the effects of continuous and pulsed US treatments by ultrasonographic imaging in addition to clinical and electrophysilogical parameters in patients with carpal tunnel syndrome (CTS).

Method: Fifty-four patients with idiopathic CTS were randomly divided into three groups.

Redefining Cut-Points for High Symptom Burden of the Global Initiative for Chronic Obstructive Lung Disease Classification in 18,577 Patients With Chronic Obstructive Pulmonary Disease.

Background: Patients with chronic obstructive pulmonary disease (COPD) can be classified into groups A/C or B/D based on symptom intensity. Different threshold values for symptom questionnaires can result in misclassification and, in turn, different treatment recommendations. The primary aim was to find the best fitting cut-points for Global initiative for chronic Obstructive Lung Disease (GOLD) symptom measures, with an modified Medical Research Council dyspnea grade of 2 or higher as point of reference.

Factors affecting the results of the functional dexterity test.

Study Design: Cross-sectional study.

Purpose Of The Study: The purpose of this study was to identify which demographic and anthropometric features affect performance (time) on the functional dexterity test (FDT).

Methods: One hundred fifty-two healthy subjects between the ages of 20 and 80 years were included in this cross-sectional study.

Comparison of effectiveness of Transcutaneous Electrical Nerve Stimulation and Kinesio Taping added to exercises in patients with myofascial pain syndrome.

Background: Although there are several studies of Transcutaneous Electrical Nerve Stimulation (TENS) and exercise in myofascial pain syndrome, there are no studies comparing the effectiveness of Kinesio Taping (KT) and TENS in myofascial pain syndrome patients.

Objective: To compare the early and late effects of TENS and KT on pain, disability and range of motion in myofascial pain syndrome patients.

Methods: Sixty-nine patients were divided into three groups randomly as TENS+Exercise, KT+Exercise and exercise groups.

Effects of weighted and un-weighted pendulum exercises on ultrasonographic acromiohumeral distance in patients with subacromial impingement syndrome.

Background: Although functional results of combined rehabilitation programs are reported, there have been no reports studying the effects of solo pendulum exercises on ultrasonographic measurements of acromiohumeral distance (AHD).

Objective: To investigate the effects of weighted and un-weighted pendulum exercises on ultrasonographic AHD and clinical symptoms in patients with subacromial impingement syndrome.

Methods: Patients with subacromial impingement syndrome were randomized to performing weighted (1.

Repetition or alternation of context influences sequential congruency effect depending on the presence of contingency.

The sequential congruency effect (SCE) is defined as the decrease in the congruency effect following incongruent trials compared to congruent trials. The effect of context repetition on the SCE was investigated in four experiments. In all the experiments, dynamic visual white noise was used as the contextual feature, and the number of congruent and incongruent trials was equal.

Tetra-ataxiometric Posturography in Patients with Migrainous Vertigo.

Background: Migraine is a common disorder characterized by headache attacks frequently accompanied by vestibular symptoms like dizziness, vertigo, and balance disorders. Clinical studies support a strong link between migraine and vertigo rather than between other headache types and vertigo or nonvertiginous dizziness. There is a lack of consensus regarding the pathophysiology of migrainous vertigo.

ISPC effect is not observed when the word comes too late: a time course analysis.

The item-specific proportion congruency (ISPC) effect is demonstrated by a smaller Stroop effect observed for mostly incongruent items compared to mostly congruent items. Currently, there is a continuing debate on whether conflict driven item-specific control processes or stimulus-response contingency learning account for the ISPC effect. In the present study, we conducted two experiments to investigate the time course of the ISPC effect with a stimulus onset asynchrony (SOA) manipulation.

Hemifacial spasm and postural abnormalities; clinical and posturographical analyses.

Hemifacial spasm (HFS) is defined as an involuntary, irregular clonic, or tonic movement of muscles innervated by the ipsilateral seventh cranial nerve. It is reported that the coexistence of non-motor- and motor-related symptoms can be seen in patients with HFS. Postural disturbances were investigated in some movement disorders; however, postural abnormalities due to HFS had not been reported before.

Cognitive function in chronic obstructive pulmonary disease: relationship to global initiative for chronic obstructive lung disease 2011 categories.

Background And Objective: Recently, comorbidities such as impaired cognitive function have been attracting more focus when considering the management of chronic obstructive pulmonary disease (COPD). Here we investigated the relationship between cognitive function and the categories given in the Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines in 2011. Specifically, after controlling for non-COPD covariates, we assessed the clinical features that may be predictive of cognitive impairment in patients with COPD.

Prednisolone in complex regional pain syndrome.

Background: Although there are several studies of systemic corticosteroid therapies in various doses and various durations in complex regional pain syndrome (CRPS), the outcome measurement parameters are limited to the range of motion measurements, edema, and symptoms of CRPS.

Objective: To investigate the effects of prednisolone on clinical symptoms, pain, hand grip strength, range of motion, as well as on functional ability and quality of life in patients who developed CRPS after traumatic upper extremity injury.

Study Design: Retrospective evaluation.

Comparison of efficacy of neural therapy and physical therapy in chronic low back pain.

The aim of this prospective study was to evaluate the effects of neural therapy, and physical therapy on level of pain, disability, quality of life, and psychological status in patients with chronic low back pain. Patients admitted to the physical therapy and rehabilitation outpatient clinic with the complaint of low back pain of at least 3 months duration. Group 1 (n=27), physical therapy (PT, hotpack, ultrasound, TENS 15 sessions), group 2 (n=33), neural therapy (NT, 1:1 mixture of 20 mg/mL Lidocaine HCl (Jetokain simplex®) and saline for 5 sessions.

The correlation of neurophysiological findings with clinical and functional status in patients following traumatic nerve injury.

In this study, we aimed to determine whether there is a correlation between the electrodiagnostic findings and the functional status, muscle strength and sensibility in patients with traumatic nerve injury to the wrists. We assessed 50 patients at a mean of 11.6 months (SD 5.