Evaluation of the predictive value of the glucose-to-potassium ratio in predicting in-hospital mortality of patients with sepsis and septic shock.

Background: In this study, we aimed to evaluate the role of the glucose-to-potassium ratio in predicting in-hospital mortality and prognosis of patients diagnosed with sepsis and septic shock in an emergency department and admitted to an emergency critical intensive care unit (ICU).

Methods: This study was a retrospective and observational evaluation of nontraumatic sepsis and septic shock patients > 18 years of age who were admitted to the emergency department of a tertiary training and research hospital and had available glucose and potassium values at the time of admission. The patients were evaluated over a 24-month period.

Improved facial emotion recognition model based on a novel deep convolutional structure.

Facial Emotion Recognition (FER) is a very challenging task due to the varying nature of facial expressions, occlusions, illumination, pose variations, cultural and gender differences, and many other aspects that cause a drastic degradation in quality of facial images. In this paper, an anti-aliased deep convolution network (AA-DCN) model has been developed and proposed to explore how anti-aliasing can increase and improve recognition fidelity of facial emotions. The AA-DCN model detects eight distinct emotions from image data.

Effects of chickpea grain feeding on the growth and carcass features of growing lambs.

An investigation was conducted to find out how diet formulation of chickpea grains (CHPE) rather than soybean meal and barely grain affected the performance, blood metabolites, carcass, and meat quality features of Awassi lambs. Thirty lambs, with an average age of 73 ± 0.85 days and an initial body weight of 21.

A Novel Multi-Scaled Deep Convolutional Structure for Punctilious Human Gait Authentication.

The need for non-interactive human recognition systems to ensure safe isolation between users and biometric equipment has been exposed by the COVID-19 pandemic. This study introduces a novel Multi-Scaled Deep Convolutional Structure for Punctilious Human Gait Authentication (MSDCS-PHGA). The proposed MSDCS-PHGA involves segmenting, preprocessing, and resizing silhouette images into three scales.

Eosinophilic Pleocytosis in the Cerebrospinal Fluid following CAR-T Cell Therapy for Central Nervous System Lymphoma: A Case for Warning?

Introduction: Chimeric antigen receptor T (CAR-T) cell therapy, emerging as an efficient treatment option for patients with secondary central nervous system (CNS) lymphoma, is frequently complicated with immune effector cell-associated neurotoxicity syndrome (ICANS).

Case Presentation: We report a case of a 64-year-old woman with transformed follicular lymphoma, developing high-grade ICANS with eosinophilic pleocytosis following third-line therapy with CAR-T cells (tisagenlecleucel). During bridging therapy, she declined neurologically and was diagnosed with secondary CNS lymphoma.

The immunopathological landscape of human pre-TCRα deficiency: From rare to common variants.

We describe humans with rare biallelic loss-of-function variants impairing pre-α T cell receptor (pre-TCRα) expression. Low circulating naive αβ T cell counts at birth persisted over time, with normal memory αβ and high γδ T cell counts. Their TCRα repertoire was biased, which suggests that noncanonical thymic differentiation pathways can rescue αβ T cell development.

Case 321: Leigh Syndrome.

A 9-month-old preterm male infant born at 33 weeks gestation presented with a 2-month history of developmental decline. The parents reported that over the past several months, they noted regression of milestones, where the infant stopped smiling, crying, expressing himself, or making eye contact. The parents also reported that the infant had multiple seizures during which he would wake up stiff and stare into space for 10-20 seconds while his lips would become blue.

Verbascoside Inhibits/Repairs the Damage of LPS-Induced Inflammation by Regulating Apoptosis, Oxidative Stress, and Bone Remodeling.

Osteocytes play an important role as regulators of both osteoclasts and osteoblasts, and some proteins that are secreted from them play a role in bone remodeling and modeling. LPS affects bone structure because it is an inflammatory factor, despite verbascoside's potential for bone preservation and healing. Osteocytes may also be involved in the control of the bone's response to immunological changes in inflammatory situations.

Effects Of Excessive Screen Time During Online Teaching On The Physical And Mental Health Of Medical And Dental Students.

To assess the effects of excessive screen time on the health of medical and dental students due to online teaching during the COVID-19 pandemic. It was a descriptive cross-sectional study, conducted in Bahria University of Health Sciences from June 2022 to September 2022 after getting ethical approval. A total of 200 students who attended online teaching modules for at least one year through online teaching Apps, were included.

Associations between HLA class II alleles and IgE sensitization to allergens in the Qatar Biobank cohort.

Background: Allergic disorders are the consequence of IgE sensitization to allergens. Population studies have shown that certain human leukocyte antigen (HLA) alleles are associated with increased or decreased risk of developing allergy.

Objective: We aimed to characterize the relationship between HLA class II allelic diversity and IgE sensitization in an understudied Arab population.

Case 321.

A 9-month-old preterm male infant born at 33 weeks gestation presented with a 2-month history of developmental decline. The parents reported that over the past several months, they noted regression of milestones, where the infant stopped smiling, crying, expressing himself, or making eye contact. The parents also reported that the infant had multiple seizures during which he would wake up stiff and stare into space for 10-20 seconds while his lips would become blue.

A robust classification of acute lymphocytic leukemia-based microscopic images with supervised Hilbert-Huang transform.

Acute lymphocytic leukemia (ALL) is a malignant condition characterized by the development of blast cells in the bone marrow and their quick dissemination into the bloodstream. It primarily affects children and individuals over the age of 60. Manual blood testing, which has been around for a long time, may be slow.

Model-based and model-free deep features fusion for high performed human gait recognition.

In the last decade, the need for a non-contact biometric model for recognizing candidates has increased, especially after the pandemic of COVID-19 appeared and spread worldwide. This paper presents a novel deep convolutional neural network (CNN) model that guarantees quick, safe, and precise human authentication via their poses and walking style. The concatenated fusion between the proposed CNN and a fully connected model has been formulated, utilized, and tested.

Inherited human ITK deficiency impairs IFN-γ immunity and underlies tuberculosis.

Inborn errors of IFN-γ immunity can underlie tuberculosis (TB). We report three patients from two kindreds without EBV viremia or disease but with severe TB and inherited complete ITK deficiency, a condition associated with severe EBV disease that renders immunological studies challenging. They have CD4+ αβ T lymphocytopenia with a concomitant expansion of CD4-CD8- double-negative (DN) αβ and Vδ2- γδ T lymphocytes, both displaying a unique CD38+CD45RA+T-bet+EOMES- phenotype.

The effects of feeding chickpea grains on the lactating performance and blood metabolites of ewes.

An experiment was conducted to see how replacing soybean meal with chickpea grains (CHPE) affected the performance, milk production, digestibility, nitrogen (N) balance, and blood metabolites of Awassi ewes. Thirty Awassi ewes with an initial body weight of 53.2 ± 2.

Impacts of substituting soybean meal with cold extraction sesame meal on growth accomplishment and health in growing Awassi lambs.

Blood metabolites and growing performing were evaluated in lambs (15.7 ± 0.33 kg; initial body weight) fed diets containing either soybean meal or cold extraction sesame meal (SM).

Inherited IFNAR1 Deficiency in a Child with Both Critical COVID-19 Pneumonia and Multisystem Inflammatory Syndrome.

Background: Inborn errors of immunity (IEI) and autoantibodies to type I interferons (IFNs) underlie critical COVID-19 pneumonia in at least 15% of the patients, while the causes of multisystem inflammatory syndrome in children (MIS-C) remain elusive.

Objectives: To detect causal genetic variants in very rare cases with concomitant critical COVID-19 pneumonia and MIS-C.

Methods: Whole exome sequencing was performed, and the impact of candidate gene variants was investigated.

[HAIR STRAIGHTENING - NOT STRAIGHTFORWARD].

The rising popularity of hair straightening in younger ages has become a medical issue, since glycolic acid and formaldehyde may be present, even in "formaldehyde-free" labeled products. Formaldehyde - a colorless material, evaporates during the hair straightening procedure, inhaled and absorbed into the blood stream causing oxidative stress and cytotoxic damage to the proximal tubule cells leading to acute kidney injury (AKI). Glycolic acid is processed to glyoxylate and eventually to oxalate, whose deposition may also cause AKI.

Predictors of Short-Term Mortality Following First Episode of Spontaneous Bacterial Peritonitis in Hospitalized Cirrhotic Patients.

Background and aims Spontaneous bacterial peritonitis (SBP) is an important cause of morbidity and mortality in patients with cirrhosis. This study aimed to identify the factors impacting morbidity and short-term mortality in a cohort of patients with cirrhosis following an index episode of SBP. Methods In a retrospective study of hospitalized cirrhotic cohort, 333 patient records were reviewed.

A Novel STK4 Mutation Impairs T Cell Immunity Through Dysregulation of Cytokine-Induced Adhesion and Chemotaxis Genes.

Purpose: Human serine/threonine kinase 4 (STK4) deficiency is a rare, autosomal recessive genetic disorder leading to combined immunodeficiency; however, the extent to which immune signaling and host defense are impaired is unclear. We assessed the functional consequences of a novel, homozygous nonsense STK4 mutation (NM_006282.2:c.