Protective effects of melatonin therapy in model for neonatal hyperoxic lung injury.

Context: Bronchopulmonary dysplasia (BPD) is a common outcome of premature birth. Currently, no effective preventive therapy is available for BPD, but the major role of O2 toxicity in the development of BPD has gained attention, particularly for developing new antioxidants for prevention. The major protective mechanism of melatonin (MT) includes free-radical scavenging activity and activation of the cyclooxygenase-prostoglandin enzyme system.

Increased fecal calprotectin in preterm infants with necrotizing enterocolitis.

Background: Necrotizing entrocolitis (NEC) remains a potentially fatal disease in premature infants despite the recent advances in neonatal care. It is a disease with a multifactorial etiology leading to the one common final pathway of necrosis and inflammmation of the neonatal intestine.

Methods: Calprotectin is a calcium and zinc-binding protein in human neutrophils.

Association between clinical severity of childhood asthma and serum leptin levels.

Objective: To investigate the association between the clinical severity of childhood asthma and serum leptin levels, to define whether the severity of asthma correlates with body mass index (BMI) or serum leptin levels and to examine the sensitivity of leptin levels in predicting asthma severity.

Methods: This study was conducted in 65 patients, aged 2 to 14 yrs with newly diagnosed asthma without any chronic co-morbidity. The subjects were distributed into three groups according to the severity of asthma.

The relationship between serum visfatin, adiponectin, and insulin sensitivity markers in neonates after birth.

Aim: The aim of this study was to assess the adiponectin and visfatin concentrations in small-for-gestational age (SGA), appropriate-for-gestational age (AGA), and large-for-gestational age (LGA) newborns and their mothers. Sixty parturients giving birth to 20 term AGA singleton infants, 20 term singleton SGA infants, and 20 term singleton LGA infants were included into the study.

Results: Mean visfatin levels were found significantly higher in the SGA (p < 0.

Cord plasma concentrations of visfatin, adiponectin and insulin in healthy term neonates: positive correlation with birthweight.

Objective: The aims of this study were to examine the relationships between adiponectin, insulin, visfatin and weight at birth in healthy term infants.

Design And Methods: Anthropometric parameters including weight, length were measured and plasma lipid profiles, insulin, visfatin and adiponectin concentrations in cord blood samples from 50 LGA and 50 AGA singleton infants born at term after uncomplicated pregnancies were assayed.

Results: Mean visfatin and adiponectin levels were significantly higher in the LGA group than AGA group (11.

Pneumococcal serotypes recovered from health children and their possible association with risk factor in istanbul, Turkey.

Unlabelled: Streptococcus pneumonia is an increasing problem worldwide and nasopharyngeal colonization plays an important role in pneumococcal infections. The aims of this study were to assess the nasopharyngeal colonization rate, investigate the risk factors for nasopharyngeal colonization with S. pneumonia, serogroup and penicillin susceptibility patterns of Streptococcus pneumoniae strains isolated from healthy children.