Thyroid function and cancer risk: a prospective population study.

Background: It has been hypothesized that thyroid function may influence cancer risk, but few studies with adequate statistical power have investigated this question, and the results have not been consistent.

Methods: In a prospective study of 29,691 people (19,710 women and 9,981 men) without previously known thyroid disease, thyrotropin was measured at baseline, and cancer incidence was recorded during 9 years of follow-up. Using Cox regression analysis, we studied the associations (hazard ratios) of thyrotropin categories with total cancer risk, and specifically, with risk of lung, colon, prostate, and breast cancer adjusted for age, sex, and smoking status.

Thyrotropin levels and risk of fatal coronary heart disease: the HUNT study.

Background: Recent studies suggest that relatively low thyroid function within the clinical reference range is positively associated with risk factors for coronary heart disease (CHD), but the association with CHD mortality is not resolved.

Methods: In a Norwegian population-based cohort study, we prospectively studied the association between thyrotropin levels and fatal CHD in 17,311 women and 8002 men without known thyroid or cardiovascular disease or diabetes mellitus at baseline.

Results: During median follow-up of 8.

Tobacco smoking and thyroid function: a population-based study.

Background: The association between tobacco smoking and thyroid function is incompletely understood.

Methods: In a cross-sectional, population-based study conducted between August 15, 1995, and June 18, 1997, of 20 479 women and 10 355 men without previously known thyroid disease, we calculated the geometric mean serum concentration of thyrotropin and the prevalence of hypothyroidism and hyperthyroidism among current, former, and never smokers.

Results: Among women, the mean thyrotropin level was lower in current (1.

The association between TSH within the reference range and serum lipid concentrations in a population-based study. The HUNT Study.

Objective: The association between TSH and serum lipids in people with no apparent thyroid disease is insufficiently understood. We have studied the association between normal thyroid function, defined as TSH within the reference range of a general population, and concentrations of serum lipids.

Design: Cross-sectional, population-based study with 30,656 individuals without known thyroid disease.

Association between blood pressure and serum thyroid-stimulating hormone concentration within the reference range: a population-based study.

Context: The association between thyroid function and blood pressure is insufficiently studied.

Objective: The objective of the investigation was to study the association between TSH within the reference range and blood pressure.

Design And Setting: This was a cross-sectional, population-based study.

[Three primary stents in extensive esophageal cancer].

Background: Most patients with oesophageal cancer have unresectable disease at initial assessment. Dysphagia is the most common symptom. Laser ablation and self-expandable metal stents are among the possible treatments for dysphagia caused by oesophageal cancer.

[Increased cardiovascular risk in patients with type 2 diabetes treated with sulfonylurea?].

Background: The use of sulphonylureas for type 2 diabetes has been debated since 1970, when the University Group Diabetes Program (UGDP) reported increased cardiovascular mortality with tolbutamide treatment.

Material And Methods: We try to present a balanced review of the current knowledge of the possible cardiovascular side effects of sulphonylureas.

Results: Recent studies on the molecular actions of sulphonylureas show that sulphonylureas, in addition to closing K+ ATP channels in insulin producing cells, also do so in the myocard and in vascular smooth muscle.