Impact of early oseltamivir treatment on outcome in critically ill patients with 2009 pandemic influenza A.

Objectives: The impact of oseltamivir on mortality in critically ill patients with 2009 pandemic influenza A (2009 H1N1) is not clear. The main objective of this study was to investigate the relationship between the timing of antiviral administration and intensive care unit (ICU) outcomes.

Methods: Prospective, observational study of a cohort of ICU patients with confirmed 2009 H1N1 infection.

Severe pandemic (H1N1)v influenza A infection: report on the first deaths in Spain.

Background And Objective: The impact of pandemic influenza A (H1N1)v infection is still unknown but it is associated with a high case-fatality rate.

Methods: This was a prospective, observational, multicentre study conducted in 144 Spanish intensive care units. Demographic and clinical data were reviewed for all cases of pandemic influenza A (H1N1)v infection reported from 23 June 2009 through 11 February 2010 and confirmed by reverse transcriptase PCR assay.

Intensive care adult patients with severe respiratory failure caused by Influenza A (H1N1)v in Spain.

Introduction: Patients with influenza A (H1N1)v infection have developed rapidly progressive lower respiratory tract disease resulting in respiratory failure. We describe the clinical and epidemiologic characteristics of the first 32 persons reported to be admitted to the intensive care unit (ICU) due to influenza A (H1N1)v infection in Spain.

Methods: We used medical chart reviews to collect data on ICU adult patients reported in a standardized form.