Publications by authors named "Asumi Koyama"
Article Synopsis
- Biologics have improved outcomes for psoriasis patients, but some end up needing to switch therapies for various reasons.
- This study analyzed 13 years of data to identify factors that lead to patients switching biologics, focusing on clinical characteristics and lab results.
- Key findings showed that higher disease severity and the presence of arthritis increased the likelihood of switching, with systemic inflammation (measured by neutrophil to lymphocyte ratio) playing a significant role in treatment adherence.
Article Synopsis
- - Psoriasis patients often need biologic treatments, particularly tumor necrosis factor (TNF) inhibitors, which can lead to the production of autoantibodies, but the link with antiphospholipid syndrome (APS) hasn't been thoroughly studied.
- - This study examined psoriasis patients on different biologics (TNF, IL-17, IL-23) to see how often they produced APS-related autoantibodies and how these correlated with their clinical condition and severity of the disease.
- - Results showed that TNF inhibitors were linked to higher rates of APS autoantibodies, especially in patients with more severe disease and arthritis, although no actual APS symptoms were reported, highlighting a complex relationship between autoimmunity
Article Synopsis
- Atopic dermatitis (AD) is a skin condition associated with chronic changes influenced by inflammation and blood vessel formation (angiogenesis), but the role of factors that inhibit angiogenesis is not well understood.
- A study focused on vasohibin-1 (VASH1), an angiogenesis inhibitory factor, found higher levels of VASH1 in the serum and skin of AD patients compared to healthy individuals.
- The research indicated a correlation between increased serum VASH1 and the duration of the disease, as well as a relationship between VASH1 and another factor related to blood vessel growth, suggesting that these processes may contribute to the worsening inflammation seen in chronic AD.
Article Synopsis
- Systemic inflammation is key to understanding psoriasis and was evaluated through various inflammatory markers in patients with psoriasis vulgaris and psoriatic arthritis.
- The study found that certain markers, like neutrophil and CRP levels, were linked to the severity of psoriasis and the likelihood of developing psoriatic arthritis.
- Higher levels of inflammatory markers before treatment were associated with lower rates of continuing conventional therapies but did not impact retention rates for biologic treatments.
Article Synopsis
- Acquired factor V inhibitor is a rare coagulation disorder, and this case involves a 76-year-old man who developed it while being treated with apixaban after heart procedures.
- He experienced multiple hemorrhages after anticoagulation therapy, leading to abnormal blood test results that confirmed the presence of the inhibitor.
- Treatment with prednisolone successfully normalized his blood clotting parameters, marking the first documented case of factor V inhibitor linked to a direct Xa inhibitor like apixaban.
Article Synopsis
- Secondary upper limb lymphoedema is caused by dysfunction in the lymphatic system, and while diagnosis relies on clinical features, there aren't clear criteria for it.
- The study introduces a new technique called SPECT-CT LSG, which provides 3D images of lymph flow pathways compared to the traditional 2D lymphoscintigraphy.
- Results showed that as lymphoedema worsens, lymphatic flow changes, with more distal backflow in the upper limb and decreased flow to lymph nodes near the clavicle, highlighting important pathological features of lymphoedema.
Article Synopsis
- The text discusses a gram-negative rod bacterium that can be transmitted through dog bites and is particularly dangerous for people with weakened immune systems, like those who have had a spleen removed or struggle with alcoholism.
- A case study of a 53-year-old man with rheumatoid arthritis illustrates how the infection led to severe complications such as sepsis and respiratory distress after being bitten by his dog.
- The case highlights the importance of considering such infections in immunocompromised patients who have experienced animal bites, as this can significantly impact their treatment and outcome.
Article Synopsis
- * After a decade, he developed splenomegaly, and a bone marrow biopsy revealed a type of lymphoma characterized by abnormal lymphocytes, leading to a diagnosis of splenic marginal zone lymphoma.
- * Initial treatment with rituximab improved his splenomegaly but did not resolve his anemia; however, switching to bendamustine ultimately resulted in the resolution of his anemia and improved overall health.
Article Synopsis
- Electronic medical record systems have made it easier to access patient clinical information, but labs may overlook abnormal data when analyzing diseases.
- A case study highlighted a patient with high lactate dehydrogenase and anemia, revealing important insights about hemolysis and potential drug impact through laboratory data analysis.
- Enhancing training for both medical technologists and clinicians on interpreting lab data and linking it to disease mechanisms could improve diagnostic accuracy and laboratory report quality.
Primary plasma cell leukemia (PPCL) is a rare disease that progresses rapidly. In such cases, it is difficult to achieve remission, and early intensive chemotherapy is recommended. We herein describe the case of a 76-year-old man with PPCL complicated by renal failure and pulmonary hypertension.
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