Protection of stromal cell-derived factor 2 by heat shock protein 72 prevents oxaliplatin-induced cell death in oxaliplatin-resistant human gastric cancer cells.

Heat shock protein 72 (Hsp72) is a molecular chaperone that assists in the folding of nascent polypeptides and in the refolding of denatured proteins. In many cancers, Hsp72 is constitutively expressed at elevated levels, which can result in enhanced stress tolerance. Similarly, following treatment with anticancer drugs, Hsp72 binds to denatured proteins that may be essential for survival.

Spatiotemporal characteristics of the neural activities processing consonant/dissonant tones in melody.

To identify neural correlates underlying melody processing, we measured MEG responses elicited by keynote and out-of-key tones at the end of musical phrases. These melodies were newly composed and unknown to the subjects. Significant enlargements of N1m/P2m peaks at about 120-160 ms were observed in response to dissonant (out-of-key) tones compared to those in response to consonant (keynote) tones.