Time- and sex-dependent effects of juvenile social isolation on mouse brain morphology.

During early life stages, social isolation disrupts the proper brain growth and brain circuit formation, which is associated with the risk of mental disorders and cognitive deficits in adulthood. Nevertheless, the impact of juvenile social isolation on brain development, particularly regarding variations across age and sex, remains poorly understood. Here, we investigate the effects of social isolation stress (SIS) during early (3-5 weeks old) or late (5-7 weeks old) juvenile period on brain morphology in adult male and female mice using ultra high-field MRI (11.

Distinct neural responses of ventromedial prefrontal cortex-projecting nucleus reuniens neurons during aversive memory extinction.

Animals adaptively regulate aversive memories in safe environments through extinction, a process central to exposure therapy for anxiety disorders. The limbic thalamus controls cognitive function in concert with interconnected cortical and limbic structures. Though medial prefrontal (mPFC) afferents to the limbic thalamus regulate aversive memory, the functional role of limbic thalamus efferents to mPFC is unclear.