Noise patterns in visceral surgical procedures: Analysis of second-by-second dBA data of 599 procedures over the course of one year.

The objective of this study is to analyze noise patterns during 599 visceral surgical procedures. Considering work-safety regulations, we will identify immanent noise patterns during major visceral surgeries. Increased levels of noise are known to have negative health impacts.

Subcutaneous immunotherapy with depigmented-polymerized allergen extracts: a systematic review and meta-analysis.

Background: Double-blind, placebo-controlled trials (DBPCTs) have confirmed the efficacy of allergen-specific immunotherapy (AIT) with depigmented-polymerized allergen extracts (DPAEs). This systematic review evaluates the efficacy of AIT using different allergens in different severity stages of rhinoconjunctivitis with or without asthma in the pollen studies and asthma and rhinitis in the house dust mite studies in comparison to placebo.

Methods: We used MEDLINE, Embase, CENTRAL and LILACS databases to review DBPCTs published until July 2016.

Liposomal Eye Spray Is as Effective as Antihistamine Eye Drops in Patients with Allergic Rhinoconjunctivitis Induced by Conjunctival Provocation Testing.

Background: Liposomal eye spray (LS) has been introduced for the treatment of dry eye. Whether LS can also relieve symptoms due to allergic rhinoconjunctivitis (ARC) has not yet been sufficiently investigated.

Objectives: The aim of this study was to assess the onset of action, the reduction of allergy symptoms, and the safety of LS - a nonpharmacological treatment option - compared with those of antihistamine eye drops (AD).

Early nonreactivity in the conjunctival provocation test predicts beneficial outcome of sublingual immunotherapy.

Background: Clinical practice needs a common parameter that can provide an early, reliable estimation of the outcome of sublingual immunotherapy (SLIT) in an upcoming pollen season. We investigated whether the conjunctival provocation test (CPT) can predict the beneficial outcome of SLIT in patients with allergic rhinoconjunctivitis after 4 weeks of treatment.

Methods: We conducted two separate prospective, randomized, double-blind, placebo-controlled, multicenter trials.

Reliability of a New Symptom Score in a Titrated Quantitative Conjunctival Provocation Test Supported by an Objective Photodocumentation.

Background: Allergen provocation tests are useful methods for proving the clinical relevance of an allergen-specific sensitization. Among these methods, the conjunctival provocation test (CPT) represents an easy-to-use tool. However, its readout parameters have not yet been internationally standardized or validated.

Lolium perenne peptide immunotherapy is well tolerated and elicits a protective B-cell response in seasonal allergic rhinitis patients.

Background: Systemic allergic reactions are a risk for allergen immunotherapy that utilizes intact allergen preparations. We evaluated the safety, efficacy and immune mechanisms of short-course treatment with adjuvant-free Lolium perenne peptides (LPP) following a 6-week dose-escalation protocol.

Methods: In a prospective, dose-escalation study, 61 grass pollen-allergic patients received 2 subcutaneous injections of LPP once weekly for 6 weeks.

A randomized, double-blind, placebo-controlled, dose-finding trial with Lolium perenne peptide immunotherapy.

Background: A novel subcutaneous allergen immunotherapy formulation (gpASIT+™) containing Lolium perenne peptides (LPP) and having a short up-dosing phase has been developed to treat grass pollen-induced seasonal allergic rhinoconjunctivitis. We investigated peptide immunotherapy containing the hydrolysate from perennial ryegrass allergens for the optimum dose in terms of clinical efficacy, immunogenicity and safety.

Methods: This prospective, double-blind, placebo-controlled, phase IIb, parallel, four-arm, dose-finding study randomized 198 grass pollen-allergic adults to receive placebo or cumulative doses of 70, 170 or 370 μg LPP.

Specific Characteristics in Digital Assessment of Conjunctival Redness.

Photodocumentation of allergic hyperemia induced during the conjunctival provocation test (CPT) is analyzed by digital imaging and by assessment from an external observer. Selected specific characteristics, derived from the measured conjunctival redness values, represent the relevance of digital imaging and reproducibility of the CPT. The characteristics discussed here are: the area under the ROC curve and Pearson's product-moment correlation coefficient.

Ultra-short-course booster is effective in recurrent grass pollen-induced allergic rhinoconjunctivitis.

Background: A relevant proportion of allergic rhinoconjunctivitis (ARC) patients experience recurrent symptoms after successfully completing allergen immunotherapy (AIT). This prospective, controlled, noninterventional study used internationally standardized instruments to determine the clinical effects of a preseasonal, ultra-short-course booster AIT on clinical outcome parameters.

Methods: This two-arm study included patients aged ≥12 years with recurrent grass pollen-induced seasonal AR who had completed a successful course of any grass pollen AIT at least 5 years before enrolment.

Digitally Analyzed Conjunctival Redness: Does Repeated Conjunctival Provocation Intrinsically Cause Local Desensitization of the Eye?

Background: Allergic reactions in patients with seasonal or perennial rhinoconjunctivitis mediated by airborne allergens can be effectively assessed with the conjunctival provocation test (CPT). The CPT is a fast and easy diagnostic procedure that challenges the ocular mucosa with instillations of allergen solutions into the conjunctival region. This paper aimed to investigate the possible influence of repeated diagnostic CPT procedures on the patient's clinical presentation, i.

Image-Based Assessment of Allergic Inflammation under Conjunctival Provocation.

Conjunctival redness is an objective allergy symptom which can be analyzed using objective computer imaging methods. To evaluate allergic inflammation of the eyes, a robust and precise image-based method was developed and applied to analyze allergic hyperemia under the conjunctival provocation test (CPT). High-resolution digital photos were taken and analyzed via digital analysis software to obtain and document conjunctival redness.

Photodocumentation of Allergic Severity under Conjunctival Provocation.

The aim of this work was to evaluate conjunctival redness as an objective allergy symptom during the conjunctival provocation test (CPT). The CPT is an instillation of ophthalmic solution containing an allergen into the ocular mucosa. Allergic severity using the CPT was evaluated in the multicenter, randomized, controlled, double-blind, dose-finding study of 159 patients with birch pollen allergy where the mucosal sensitivity of the eye was assessed based on subjective and objective symptoms such as itching and redness, respectively.

Quantitative conjunctival provocation test for controlled clinical trials.

Background: The conjunctival provocation test (CPT) is a diagnostic procedure for the assessment of allergic diseases. Photographs are taken before and after provocation increasing the redness of the conjunctiva due to hyperemia.

Objective: We propose and evaluate an automatic image processing pipeline for objective and quantitative CPT.

Objectifying the conjunctival provocation test: photography-based rating and digital analysis.

Background: Patients with allergic rhinoconjunctivitis are susceptible to both nasal and ocular symptoms. The conjunctival provocation test (CPT) is an established diagnostic procedure used in allergic rhinoconjunctivitis, particularly to document a patient's current reactivity to allergens. To date, there are no international guidelines defining the CPT.

Determination of the strange-quark density of the proton from ATLAS measurements of the W→ℓν and Z→ℓℓ cross sections.

A QCD analysis is reported of ATLAS data on inclusive W(±) and Z boson production in pp collisions at the LHC, jointly with ep deep-inelastic scattering data from HERA. The ATLAS data exhibit sensitivity to the light quark sea composition and magnitude at Bjorken x∼0.01.

Search for pair production of a heavy up-type quark decaying to a W boson and a b quark in the lepton + jets channel with the ATLAS detector.

A search is presented for production of a heavy up-type quark (t') together with its antiparticle, assuming subsequent decay to a W boson and a b quark, t't[over ¯]'→W(+)bW(-)b[over ¯]. The search is based on 1.04 fb(-1) of proton-proton collisions at √[s]=7 TeV collected by the ATLAS detector at the CERN Large Hadron Collider.

Search for a light Higgs boson decaying to long-lived weakly interacting particles in proton-proton collisions at sqrt[s] = 7 TeV with the ATLAS detector.

A search for the decay of a light Higgs boson (120-140 GeV) to a pair of weakly interacting, long-lived particles in 1.94 fb(-1) of proton-proton collisions at sqrt[s] = 7 TeV recorded in 2011 by the ATLAS detector is presented. The search strategy requires that both long-lived particles decay inside the muon spectrometer.

Search for gluinos in events with two same-sign leptons, jets, and missing transverse momentum with the ATLAS detector in pp collisions at sqrt[s]=7 TeV.

A search is presented for gluinos decaying via the supersymmetric partner of the top quark using events with two same-sign leptons, jets, and missing transverse momentum. The analysis is performed with 2.05  fb(-1) of integrated luminosity from pp collisions at sqrt[s]=7  TeV collected by the ATLAS detector at the LHC.

Observation of spin correlation in tt¯ events from pp collisions at √s=7 TeV using the ATLAS detector.

A measurement of spin correlation in tt[over ¯] production is reported using data collected with the ATLAS detector at the LHC, corresponding to an integrated luminosity of 2.1 fb(-1). Candidate events are selected in the dilepton topology with large missing transverse energy and at least two jets.

Search for production of resonant states in the photon-jet mass distribution using pp collisions at √s=7 TeV collected by the ATLAS detector.

This Letter describes a model-independent search for the production of new resonant states in photon+jet events in 2.11 fb(-1) of proton-proton collisions at √s=7 TeV. We compare the photon+jet mass distribution to a background model derived from data and find consistency with the background-only hypothesis.

Search for down-type fourth generation quarks with the ATLAS detector in events with one lepton and hadronically decaying W bosons.

This Letter presents a search for pair production of heavy down-type quarks decaying via b' → Wt in the lepton + jets channel, as b'b' → W- tW+ t → bbW+ W- W+ W- → l± νbbqqqqqq. In addition to requiring exactly one lepton, large missing transverse momentum, and at least six jets, the invariant mass of nearby jet pairs is used to identify high transverse momentum W bosons. In data corresponding to an integrated luminosity of 1.

Search for scalar bottom quark pair production with the ATLAS detector in pp collisions at sqrt[s]=7 TeV.

The results of a search for pair production of the scalar partners of bottom quarks in 2.05  fb(-1) of pp collisions at sqrt[s]=7  TeV using the ATLAS experiment are reported. Scalar bottom quarks are searched for in events with large missing transverse momentum and two jets in the final state, where both jets are identified as originating from a bottom quark.

Observation of a new χ(b) state in radiative transitions to Υ(1S) and Υ(2S) at ATLAS.

The χ(b)(nP) quarkonium states are produced in proton-proton collisions at the Large Hadron Collider at sqrt[s] = 7  TeV and recorded by the ATLAS detector. Using a data sample corresponding to an integrated luminosity of 4.4  fb(-1), these states are reconstructed through their radiative decays to Υ(1S,2S) with Υ → μ+ μ-.

Search for the standard model Higgs boson in the diphoton decay channel with 4.9 fb(-1) of pp collision data at √s=7 TeV with ATLAS.

A search for the standard model Higgs boson is performed in the diphoton decay channel. The data used correspond to an integrated luminosity of 4.9 fb(-1) collected with the ATLAS detector at the Large Hadron Collider in proton-proton collisions at a center-of-mass energy of √s=7 TeV.

Search for the Higgs boson in the H→WW(*)→ℓ(+)νℓ(-)ν decay channel in pp collisions at √s=7 TeV with the ATLAS detector.

A search for the Higgs boson has been performed in the H→WW(*)→ℓ(+)νℓ(-)ν[over ¯] channel (ℓ=e/μ) with an integrated luminosity of 2.05 fb(-1) of pp collisions at √s=7 TeV collected with the ATLAS detector at the Large Hadron Collider. No significant excess of events over the expected background is observed and limits on the Higgs boson production cross section are derived for a Higgs boson mass in the range 110 GeV View Article and Find Full Text PDF