White saffron ( Val.) attenuates diabetes and improves pancreatic β-cell regeneration in streptozotocin-induced diabetic rats.

Diabetes is a chronic disease caused by an imbalance of insulin release to the bloodstream in response to excessive glucose influx, which causes hyperglycemia. White saffron ( Val.), an Indonesian aromatic spice, contains essential phytochemicals and has a number of potential health benefits.

Hypoglycemic Activity of Val. Extract via Modulation of GLUT4 and PPAR-γ mRNA Expression in 3T3-L1 Adipocytes.

Background: There would be over 600 million people living with diabetes by 2040 as predicted by the World Health Organization. Diabetes is characterized by raised blood sugar and insulin resistance. Insulin regulates the influx of glucose into the cell by upregulating the glucose transporter type 4 (GLUT4) expression on the plasma membrane.

Cosmeceutical potentials of Val. extract in human BJ fibroblasts against MMP1, MMP3, and MMP13.

Oxidative stress, the disrupted oxidation-reduction mechanism in our body, is caused by the excessive exposure of free radicals and the impaired antioxidant defenses that can accelerate skin aging. Antioxidants can be obtained from nature, which are available widely in therapeutic-rich plants, such as white saffron ( Val., denoted as ).