Publications by authors named "Astrid Vernemmen"
Article Synopsis
- The study examines the effectiveness of targeted RNA-based sequencing (targeted RNA-seq) compared to traditional fluorescence in situ hybridization (FISH) for identifying gene fusions in soft tissue and bone tumors.
- Targeted RNA-seq found gene fusions in 35.9% of 131 samples and showed high negative concordance with FISH, but also detected cases that FISH missed.
- The research suggests that incorporating targeted RNA-seq into the diagnostic process improves accuracy and diagnosis in some cases, identifying four novel fusion transcripts whose clinical significance is still unknown.
Aims: Inflammatory myofibroblastic tumour (IMT) is a rare mesenchymal neoplasm of intermediate malignant potential, occurring at any age and at multiple sites. Epithelioid inflammatory myofibroblastic sarcoma (EIMS) is an aggressive subtype of IMT, typically involving the abdomen. Most IMTs harbour kinase gene fusions, especially involving ALK and ROS1, but 20-30% of IMTs show no detectable translocations.
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- Some cancer patients (1-10%) can develop skin growths called cutaneous metastases, which can be tricky to diagnose, especially if doctors don’t know where the original cancer started.
- Researchers at a medical center looked at 152 cases of these skin metastases from 2007 to 2021 to understand them better.
- The most common types of original cancers were breast and lung cancers for women, and gastrointestinal and lung cancers for men; sometimes, these skin growths were the first signs of hidden cancers inside the body.
Article Synopsis
- A woman had trouble breathing because of blood in the heart sac (hemopericardium).
- Doctors tried different tests and treatments but couldn’t find out why this was happening.
- After more surgery, they finally found out that her condition was caused by a rare cancer called angiosarcoma.