Publications by authors named "Astrid Sandnes"

Article Synopsis
  • Exercise-induced laryngeal obstruction (EILO) is a common issue among young people during intense exercise, characterized by abnormal laryngeal movement that affects breathing, and requires continuous observation for accurate diagnosis.
  • The study will randomly assign patients with EILO to different non-invasive treatment methods to assess their effectiveness, including combinations of breathing advice, muscle training, and speech therapy, followed by potential surgical options for those who do not respond.
  • This research aims to fill the gap in evidence-based treatments for EILO and is deemed ethically sound, contributing important findings requested by the European Respiratory Society for better clinical practices.
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Complaints of breathlessness during heavy exercise is common in children and adolescents, and represent expressions of a subjective feeling that may be difficult to verify and to link with specific diagnoses through objective tests. Exercise-induced asthma and exercise-induced laryngeal obstruction are two common medical causes of breathing difficulities in children and adolescents that can be challenging to distinguish between, based only on the complaints presented by patients. However, by applying a systematic clinical approach that includes rational use of tests, both conditions can usually be diagnosed reliably.

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Purpose: Exercise-induced laryngeal obstruction (EILO) is relatively common in young people. Treatment rests on poor evidence; however, inspiratory muscle training (IMT) has been proposed a promising strategy. We aimed to assess laryngeal outcomes shortly after IMT, and to compare self-reported symptoms with a control group 4-6 years later.

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Background: The diagnosis of pulmonary tularaemia can be challenging. We present a case illustrating how pulmonary tularaemia may be an important radiological differential diagnosis to lung cancer.

Case Presentation: A man in his fifties presented with several weeks of dry cough, weight loss and profuse night sweats.

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Exercise induced laryngeal obstruction (EILO) is relatively common in adolescents, with symptoms often confused with exercise induced asthma. EILO often starts with medial or inward rotation of supraglottic structures of the larynx, whereas glottic adduction appears as a secondary phenomenon in a majority. Therefore, surgical treatment (supraglottoplasty) is used in thoroughly selected and highly motivated patients with pronounced symptoms and severe supraglottic collapse.

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Article Synopsis
  • - Exercise-induced laryngeal obstruction (EILO) affects many athletes and is linked to symptoms like shortness of breath and chest tightness, with potential benefits from inspiratory muscle training (IMT).
  • - In a study with 28 athletes aged 16.4, a 6-week IMT program led to symptom improvement in 79% of participants, significant changes in the laryngeal function, and better ventilation during peak exercise.
  • - The findings suggest IMT could be an effective conservative treatment for certain EILO cases, highlighting the need for further controlled studies to explore these results.
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Background: Respiratory complications represent the major cause of death in amyotrophic lateral sclerosis (ALS). Noninvasive respiratory support is the mainstay therapy, but treatment becomes challenging as the disease progresses, possibly due to a malfunctioning larynx, which is the entrance to the airways. We studied laryngeal response patterns to mechanically assisted cough (mechanical insufflation-exsufflation) as ALS progresses.

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Background: Most patients with amyotrophic lateral sclerosis (ALS) are treated with mechanical insufflation-exsufflation (MI-E) in order to improve cough. This method often fails in ALS with bulbar involvement, allegedly due to upper-airway malfunction. We have studied this phenomenon in detail with laryngoscopy to unravel information that could lead to better treatment.

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Objective: Mechanical insufflation-exsufflation (MI-E) is used to assist cough in patients with neuromuscular diseases. Clinically, application may be challenging in some patient groups, possibly related to laryngeal dysfunction. Before launching a study in patients, the authors investigated laryngeal responses to MI-E in healthy individuals.

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Background: Inspiratory muscle training (IMT) has been used to treat patients with exercise-induced vocal cord dysfunction (VCD); the theoretical basis being the close relationship between the diaphragm and the posterior cricoarytenoid muscle, which is the main abductor of the larynx. Before launching a treatment protocol in patients with VCD, we aimed to substantiate this theory by performing laryngoscopy in healthy subjects during standardized IMT programs.

Methods: Twenty healthy volunteers at mean age 24 years were examined with video-recorded continuous transnasal flexible laryngoscopy while performing standardized training programs using a resistive loading IMT device (Respifit S).

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