Publications by authors named "Astrid Linde Basse"
The ribotoxic stress response (RSR) is a signaling pathway in which the p38- and c-Jun N-terminal kinase (JNK)-activating mitogen-activated protein kinase kinase kinase (MAP3K) ZAKα senses stalling and/or collision of ribosomes. Here, we show that reactive oxygen species (ROS)-generating agents trigger ribosomal impairment and ZAKα activation. Conversely, zebrafish larvae deficient for ZAKα are protected from ROS-induced pathology.
View Article and Find Full Text PDFLactate is a circulating metabolite and a signalling molecule with pleiotropic physiological effects. Studies suggest that lactate modulates energy balance by lowering food intake, inducing adipose browning and increasing whole-body thermogenesis. Yet, like many other metabolites, lactate is often commercially produced as a counterion-bound salt and typically administered in vivo through hypertonic aqueous solutions of sodium L-lactate.
View Article and Find Full Text PDFTissue sensitivity and response to exercise vary according to the time of day and alignment of circadian clocks, but the optimal exercise time to elicit a desired metabolic outcome is not fully defined. To understand how tissues independently and collectively respond to timed exercise, we applied a systems biology approach. We mapped and compared global metabolite responses of seven different mouse tissues and serum after an acute exercise bout performed at different times of the day.
View Article and Find Full Text PDFArticle Synopsis
- Timing of food intake and exercise plays a crucial role in energy metabolism, but the effects of exercise might vary depending on when it's performed throughout the day.
- Research using advanced techniques reveals that exercise in the early active phase activates distinct metabolic processes, particularly glycolysis, while exercise in the early rest phase shows different metabolic responses.
- The study highlights that HIF1α activation is time-dependent during exercise, influencing energy source use and overall energy balance, underscoring the importance of when exercise occurs for optimizing metabolic health.
Article Synopsis
- High fat diets in mice show that the kind of protein used can influence weight gain and fat accumulation, with casein being the most effective in preventing obesity.
- Mice fed casein maintained healthier brown adipose tissue and exhibited higher expression of UCP1, a protein that helps regulate fat metabolism, compared to those fed pork or other protein sources.
- Reducing the protein to carbohydrate ratio in diets, especially those containing pork, led to increased fat gain, indicating that not all high protein diets offer the same protective benefits against obesity.