Publications by authors named "Astrid Kindt"
Article Synopsis
- Neurofilament light chain (NFL) levels are significantly elevated in the cerebrospinal fluid and plasma of neurosarcoidosis patients compared to those with extra-neurologic sarcoidosis and healthy controls.
- The study found a median NFL level of 2304 pg/mL in cerebrospinal fluid for neurosarcoidosis patients, highlighting NFL's potential as a biomarker for disease activity.
- Higher NFL levels correlated with the severity of inflammation seen in MRI, indicating that they could be effective in distinguishing neurosarcoidosis patients from other groups.
Objective: To evaluate retinal oxygen metabolism by retinal oximetry for ocular and CNS diseases in a cross-sectional study of sarcoidosis.
Methods: Overall 201 eyes from 103 biopsy-verified sarcoidosis patients were included and divided into four groups depending on the organ affection: (i) sarcoidosis without ocular or CNS affection, (ii) ocular sarcoidosis, (iii) CNS sarcoidosis, and (iv) combined ocular and CNS sarcoidosis. Retinal oximetry was obtained and analysed, with the mean retinal arteriolar and venular saturation as well as arteriovenous difference as principal outcomes.