Publications by authors named "Astrid Hofer"
Article Synopsis
- * A study involving healthy individuals on a high-fructose diet for 8 weeks sought to understand its impact on glucose and lipid metabolism across various organs, compared to those with NAFLD as controls.
- * Results showed that while high fructose did not significantly change overall dietary intake or lead to major metabolic disturbances in healthy participants, it did exacerbate issues in NAFLD patients, highlighting the complex relationship between fructose, metabolism, and liver health.
Increased myocardial lipid content (MYCL) recently has been linked to the development of cardiomyopathy in diabetes. In contrast to steatosis in skeletal muscle and liver, previous investigations could not confirm a link between MYCL and insulin resistance. Thus, we hypothesized that cardiac steatosis might develop against the background of the metabolic environment typical for prediabetes and early type 2 diabetes: combined hyperglycemia and hyperinsulinemia.
View Article and Find Full Text PDFBackground: Several endocrine abnormalities, including hypothyroidism and Cushing's syndrome (CS), are considered as causative factors of obesity. The aim of this study was to evaluate the prevalence of endocrine disorders and obesity-associated co-morbidities, as well as the impact of substantial weight loss.
Methods: Screening was performed in 433 consecutive morbidly obese patients (age 41 ± 12 years; BMI 47 ± 6.
Objective: Statins may exert pleiotropic effects on insulin action that are still controversial. We assessed effects of high-dose simvastatin therapy on peripheral and hepatic insulin sensitivity, as well as on ectopic lipid deposition in patients with hypercholesterolemia and type 2 diabetes.
Research Design And Methods: We performed a randomized, double-blind, placebo-controlled, single-center study.
Objective: The relationship between splanchnic glucose uptake (SGU) after oral glucose administration and metabolic control in type 1 diabetic patients is controversial. We estimated SGU as well as peripheral glucose uptake and the time required for glucose absorption by a validated method, the oral glucose (OG) clamp, in type 1 diabetic patients with different levels of long-term glycemic control.
Research Design And Methods: An OG clamp (which combines a hyperinsulinemic clamp [120 mU.