Publications by authors named "Astrid Hernandez-Sierra"
Article Synopsis
- Kaposi's sarcoma (KS) is a common tumor that can occur after organ transplants, and this study investigates its connection to the HHV-8 virus and the mTOR signaling pathway in skin KS cases from renal transplant recipients.
- The research focused on twelve patients, analyzing tumor tissue for various molecular markers and classifying KS lesions by their development stage (patch, plaque, nodule).
- Findings revealed that HHV-8 was present in all samples, with increased activation of the mTOR pathway correlating to more advanced KS stages, and patients showed complete lesion disappearance when treated with mTOR inhibitors after an average follow-up of over 14 years.
BACKGROUND Polyclonal anti-thymocyte globulins (ATGs) are immunosuppressive drugs widely used in induction of immunosuppression and treatment of acute rejection after solid organ transplantation. We have previously demonstrated that ATGs bind to endothelial cells in vitro, and are able to modulate ECs. The aim of this study was to investigate the binding of ATGs to endothelial cells under in vivo conditions.
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