Validity of self-reported hysterectomy and oophorectomy in a population-based cohort: The HUNT study.

Objective: To validate self-reported hysterectomy and bilateral oophorectomy.

Design: Validation study.

Setting: Large population-based cohort study in Norway: The Trøndelag Health Study (HUNT).

All-cause and cardiovascular mortality after hysterectomy and oophorectomy in a large cohort (HUNT2).

Introduction: Hysterectomy and bilateral oophorectomy are common major surgical procedures that have been associated with increased mortality risk. We aimed to assess the association of hysterectomy and/or bilateral oophorectomy with all-cause and cardiovascular mortality in a Norwegian population.

Material And Methods: Cohort study with data from The Trøndelag Health Study (HUNT2) linked to the Norwegian Cause of Death Registry, with follow-up from 1996 until 2014 or death.

Risk of cardiovascular disease after preventive salpingo-oophorectomy.

Introduction: Breast cancer susceptibility gene (BRCA) mutation carriers are recommended to undergo early oophorectomy to prevent ovarian cancer. Premature loss of ovarian hormones may increase the risk of cardiovascular disease. Because women with preventive oophorectomy are mainly young and healthy, they rarely undergo specialized cardiological surveillance.

Symptom Experience and Self-rated Physical Functioning in Patients With Ovarian Cancer Receiving Chemotherapy: A Longitudinal Study.

Objectives: In this longitudinal study, we investigated occurrence of multiple symptoms during chemotherapy in patients with ovarian cancer. We also evaluated whether self-rated physical functioning, selected demographic, and clinical variables were associated with symptom burden over time.

Methods And Materials: In total, 82 patients provided longitudinal data (4 time points) by completing questionnaires including the Memorial Symptom Assessment Scale, the Karnofsky Performance Status Scale, and the Self-Administered Comorbidity Questionnaire.

Hormone Levels and Sexual Functioning After Risk-Reducing Salpingo-Oophorectomy.

Introduction: Women after risk-reducing salpingo-oophorectomy (RRSO) can have impaired sexual functioning, but whether there is an association between hormone levels and sexual functioning is unclear.

Aim: To determine whether hormone levels are associated with sexual functioning in women after RRSO.

Methods: This is a retrospective cohort study of 198 sexually active and 91 inactive women after RRSO.

Use of hormone replacement therapy after risk-reducing salpingo-oophorectomy.

Introduction: After premenopausal risk-reducing salpingo-oophorectomy (RRSO) to prevent ovarian cancer, the non-cancer-related morbidity and mortality may be increased if sex hormones are not replaced. Several guidelines recommend systemic hormone replacement therapy (HRT) to these women until the expected age of menopause. We aimed to study the use of HRT after RRSO.

Sexual activity and functioning after risk-reducing salpingo-oophorectomy: Impact of hormone replacement therapy.

Objective: To examine sexual activity and functioning in women after risk-reducing salpingo-oophorectomy (RRSO) compared with the general population (NORM).

Methods: Retrospective cohort study. 294 women who underwent RRSO and 1228 women from the NORM group provided written information based on mailed questionnaires.

Association between hysterectomy with ovarian preservation and cardiovascular disease in a Norwegian population-based sample.

Background/aims: Some previous studies have reported that hysterectomy predicts increased prevalence of cardiovascular diseases, but the findings are disputed. We aimed to examine associations between hysterectomy and cardiovascular disease in a Norwegian cross-sectional health study.

Methods: The data were obtained from the population-based cross-sectional Nord-Trøndelag Health Study (The HUNT-2 Study).

"The impact of cancer scale" version 1: psychometric testing of the Norwegian translation in a heterogeneous sample of cancer survivors.

Purpose: The impact of cancer scale version 1 (IOC-1) from 2006 has only been tested psychometrically in a heterogeneous sample of 193 American long-term cancer survivors (LTSs). The Norwegian version of IOC-1 compares the psychometric findings of that study with those observed in a heterogeneous sample of 809 Norwegian LTSs.

Methods: We performed exploratory (EFA) and confirmatory (CFA) factor analyses, tests of internal consistency, correlational studies with various other tests and a change over time examination in order to test reliability and validity of the IOC-1.

Follow-up routines in gynecological cancer - time for a change?

Objective: To determine current practice of follow-up of Norwegian gynecological cancer patients, and to review available randomized controlled trials (RCTs) in gynecologic, breast and colorectal cancer patients in order to discuss whether such studies are feasible in gynecological cancer patients.

Design: A combined questionnaire study and a systematic review of RCTs in follow-up of gynecological, breast, and colorectal cancers.

Population: Gynecological, breast, and colorectal cancer patients.

Prevalence and determinants of metabolic syndrome and elevated Framingham risk score in epithelial ovarian cancer survivors: a controlled observational study.

Bilateral oophorectomy has been associated with increased risk of metabolic syndrome (MetS) and coronary heart disease; however, the risk in women oophorectomized for epithelial ovarian cancer has not been studied previously. Among 287 epithelial ovarian cancer survivors (EOCSs) alive in 2004 and treated with bilateral oophorectomy between 1979 and 2003 at the Norwegian Radium Hospital, 189/287 (66%) participated and 165/189 (87%) provided demographic and health history data and fasting serum samples. Controls were women from the general population.

Morbidity associated with "self-rated health" in epithelial ovarian cancer survivors.

Background: Epithelial ovarian cancer survivors (EOCSs) frequently report multiple complaints after their treatment. The objective was to study somatic and mental morbidity in EOCSs associated with their Self-Rated Health (SRH) assessed by a single item.Findings were compared to age-matched controls from the general population.

Bilateral oophorectomy before 50 years of age is significantly associated with the metabolic syndrome and Framingham risk score: a controlled, population-based study (HUNT-2).

Objective: Bilateral oophorectomy (BOE) is often recommended in order to prevent cancer at hysterectomy for non-malignant diseases and when familial risk of ovarian and breast cancer has been identified. Surgical menopause increases the risk of cardiovascular mortality, however, the intervening mechanisms are not clear. We compared the prevalence of the metabolic syndrome (MetS) and Framingham cardiovascular risk scores in women with BOE before 50 years of age to age-matched controls in a population-based study.

A controlled study of sexual activity and functioning in epithelial ovarian cancer survivors. A therapeutic approach.

Objectives: To explore sexual activity and functioning in epithelial ovarian cancer survivors (EOCSs) compared to age-adjusted controls from the general population (NORM) with focus on findings that should be given therapeutic considerations.

Methods: A cross-sectional study of 189/287 (66%) EOCSs treated at The Norwegian Radiumhospital 1979-2003 using a mailed questionnaire including demographic and somatic issues, and schedules concerning sexuality, fatigue, mental distress and quality of life. Blood tests for sex hormone determination were taken at their GPs.

Controlled study of fatigue, quality of life, and somatic and mental morbidity in epithelial ovarian cancer survivors: how lucky are the lucky ones?

Purpose: There are few studies of somatic and mental morbidity in epithelial ovarian cancer survivors (EOCSs). The aim of this controlled, cross-sectional study was to explore fatigue, quality of life (QOL), and somatic and mental morbidity in EOCSs.

Patients And Methods: Among 287 EOCSs treated according to protocols at The Norwegian Radium Hospital between 1977 and 2003, 189 patients (66%) participated.