In Silico Characterization of the Interaction between the PBP2a "Decoy" Protein of Resistant and the Monomeric Units of Eudragit E-100 and Poly(Maleic Acid--Octadecene) Polymers.

Antimicrobial treatment alternatives for methicillin-resistant (MRSA) are increasingly limited. MRSA strains are resistant to methicillin due to the formation of β-lactamase enzymes, as well as the acquisition of the mecA gene, which encodes the penicillin-binding protein (PBP2a) that reduces the affinity for β-lactam drugs. Previous studies have shown that the use of ampicillin-loaded nanoparticles can improve antimicrobial activity on resistant strains.

Use of Autologous Serum Tears for the Treatment of Ocular Surface Disease From Patients With Systemic Autoimmune Diseases.

Purpose: To describe the safety and efficacy of autologous serum tears (AST) in managing ocular surface disease resistant to conventional therapy in patients with systemic autoimmune disease(s).

Design: Retrospective, interventional case series.

Methods: Records of patients from 2009 to 2015 with systemic autoimmune disease treated with AST (20%-50%) for chronic surface disease were analyzed.

Management of patients with confirmed and presumed mucous membrane pemphigoid undergoing entropion repair.

Purpose: To describe the outcomes and medical management necessary to achieve successful lid surgery in patients with biopsy-confirmed and presumed mucous membrane pemphigoid.

Design: Retrospective, interventional case series.

Methods: We included patients with positive biopsy results and cases with a typical clinical active bilateral presentation with negative biopsy results but classic features.