Detection by fluorescence of pituitary neuroendocrine tumour (PitNET) tissue during endoscopic transsphenoidal surgery using bevacizumab-800CW (DEPARTURE trial): study protocol for a non-randomised, non-blinded, single centre, feasibility and dose-finding trial.

Introduction: Achieving gross total resection and endocrine remission in pituitary neuroendocrine tumours (PitNET) can be challenging, especially in PitNETs with cavernous sinus (CS) invasion, defined as a Knosp grade of 3 or 4. A potential target to identify PitNET tissue is vascular endothelial growth factor A (VEGF-A), which expression is known to be significantly higher in PitNETs with CS invasion.

Methods And Analysis: The aim of this non-randomised, non-blinded, single centre, feasibility and dose-finding phase 1 trial is to determine the feasibility of intraoperative fluorescence imaging detection of PitNET tissue during endoscopic transsphenoidal surgery using the VEGF-A targeting optical agent bevacizumab-800CW (4, 5, 10 or 25 mg).

Calculating nasoseptal flap dimensions: a cadaveric study using cone beam computed tomography.

We hypothesize that three-dimensional imaging using cone beam computed tomography (CBCT) is suitable for calculating nasoseptal flap (NSF) dimensions. To evaluate our hypothesis, we compared CBCT NSF dimensions with anatomical dissections. The NSF reach and vascularity were studied.

Epistaxis caused by a dural AV-fistula at the cribriform plate.

Objectives/hypothesis: A dural arteriovenous fistula (DAVF) with cortical venous reflux (CVR) is a dangerous neurovascular entity. A DAVF at the cribriform plate is typically silent until its inevitable presentation with intracranial hemorrhage.

Case Summary: A 67-year-old male presented with severe epistaxis.

Unilateral hyperlucent lung in a child caused by a foreign body identified with v/q scintigraphy.

A 5-year-old girl presented with episodes of coughing, inspiratory stridor, and occasionally squeaking breath sounds. There was no history of a foreign body aspiration. Initially, she was diagnosed with allergic asthma.

Cranialization of the frontal sinus--the final remedy for refractory chronic frontal sinusitis.

Object: Chronic sinusitis can be a debilitating disease with significant impact on quality of life. Frontal sinusitis has a relatively low prevalence, but complications can be severe due to its anatomical location. After failure of conservative measures, typically endoscopic procedures are performed to improve the drainage of the frontal sinus.

Communicative abilities in toddlers and in early school age children with cleft palate.

Objectives: Evaluation of improvement in communicative abilities in children with nonsyndromic cleft palate.

Methods: Longitudinal retrospective case history study. Out of 117 children with cleft lip and/or cleft palate born in 1998, 1999 and 2000 and enrolled in the cleft palate team of the University Medical Centre Groningen (UMCG), 63 children were included in the study; 29 (46%) boys and 34 (54%) girls.

Nasal growth and maturation age in adolescents: a systematic review.

Objective: To define the end of the nasofacial growth spurt in order to schedule rhinoseptoplasty in patients with cleft without disturbing nasofacial growth.

Data Sources: We searched the PubMed and Cochrane bibliographic databases from inception through December 31, 2007, using the primary indexing term facial growth with the confining search terms growth AND (face OR nose) AND (cephalometry OR anthropometry). The reference lists of the retrieved articles were searched for missed relevant studies.

Evaluation of the relation between audiometric and psychometric measures of hearing after tympanoplasty.

The objective of this prospective study was to evaluate the relation between audiometric and psychometric measures after tympanoplasty from the perspective of preoperative selection of patients and postoperative assessment of the results of reconstructive middle ear surgery. Hearing (dis)ability was measured by means of pure-tone audiometry and a validated self-assessment questionnaire: the (modified) Amsterdam Inventory of Auditory Disability and Handicap (m)AIAD. Average hearing thresholds and (m)AIAD scores were evaluated for 80 patients, pre- and 12 months postoperatively.