Publications by authors named "Astin Worden"
Background: In patients with cirrhosis and acute kidney injury (AKI), longer time to AKI-recovery may increase the risk of subsequent major-adverse-kidney-events (MAKE).
Aims: To examine the association between timing of AKI-recovery and risk of MAKE in patients with cirrhosis.
Methods: Hospitalised patients with cirrhosis and AKI (n = 5937) in a nationwide database were assessed for time to AKI-recovery and followed for 180-days.
A woman in her 70s presented with acute bilateral retro-orbital headache, diplopia, chemosis and eye swelling. Ophthalmology and neurology were consulted after detailed physical examination and diagnostic workup including laboratory analysis, imaging and lumbar puncture. The patient was diagnosed with non-specific orbital inflammation and was started on methylprednisolone and dorzolamide-timolol for intraocular hypertension.
View Article and Find Full Text PDFBackground: The prognostic impact of acute kidney injury (AKI) recovery patterns in critically ill patients with cirrhosis is unknown. We aimed to compare mortality stratified by AKI recovery patterns and identify predictors of mortality in patients with cirrhosis and AKI admitted to the intensive care unit.
Materials And Methods: Patients with cirrhosis and AKI from 2016 to 2018 at 2 tertiary care intensive care units were analyzed (N=322).
Article Synopsis
- The study investigates mortality differences between critically ill patients with severe alcohol-associated hepatitis (sAH) and those with acute-on-chronic liver failure (ACLF) not caused by sAH, focusing on implications for prognosis and liver transplantation timing.
- A total of 463 ACLF patients were analyzed, revealing that those with sAH were younger and had significantly higher illness severity scores; they also faced a higher cumulative incidence of death at various time points (30, 90, and 180 days).
- After adjusting for other factors, results indicated that patients with sAH ACLF had a considerably higher risk of mortality compared to their non-sAH counterparts, underscoring the severity of sAH in critically ill patients.