Structure-function dynamics of engineered, modular neuronal networks with controllable afferent-efferent connectivity.

Microfluidic devices interfaced with microelectrode arrays have in recent years emerged as powerful platforms for studying and manipulatingneuronal networks at the micro- and mesoscale. By segregating neuronal populations using microchannels only permissible to axons, neuronal networks can be designed to mimic the highly organized, modular topology of neuronal assemblies in the brain. However, little is known about how the underlying topological features of such engineered neuronal networks contribute to their functional profile.