[Efficacy of the Russian anthelmintic agent trichlorophen].

Experiments have established the high efficacy of combinations of the micronized dosage form of trichlorophen, with albendazole or medamine in treating trichocephaliasis (its causative agent being Trichocephalus muris) in DBA/2st mice and that of trichlorophen in combination with azinox or fenasal in outbred albino mice with hymenolepiasis (its causative agent being Hymenolepis nana). These combinations are promising in treating patients with cestodosis and nemadosis, respectively.

[Activity of the anthelmintic agent trichlorophen on the models of human helminthiasis].

Trials of trichlorophen have shown its high efficacy on models of cestode infections: hymenolepiasis (at the adult and cysticercoid stages of development on three types of animals: outbred albino mice, albino rats and golden hamsters), preimaginal echinococciasis alveolaris, larval alveolar echinococciasis (at the early stage of development of the parasite in experiments on cotton rats). The high nematodical activity of trichlorophen was first found on models of trichocephaliasis in DBA/2y mice, nippostrongyloidiasis (in in vitro experiments), and aspiculuriasis in outbred mice. The agent proved to be ineffective at the tissue developmental stage of Hymenolepsis nana (H.

[The technology for manufacturing antiparasitic preparations. 9. The new preparation tizanox and an evaluation of its anti-Hymenolepis activity].

The paper describes a procedure for manufacturing the new anthelminthic Tizanox. It shows it necessary to administer a larger dose of the drug than that of azinox (praziquantel) to treat experimental hymenolepiasis. However, the lower toxicity of Tizanox enhances its chemotherapeutical index.

[The search for new antiparasitic agents. 18. The synthesis and antitrichinelliasis activity of 1-[(2-acylamino)phenyl]-3,4-dihydroisoquinolines].

New 1-[(2-acylamino)phenyl]-3, 4-dihydroisoquinolines were synthesized and tested for their acute toxicity and antitrichinosis activity. The above compounds were found to show their low toxicity and two compounds (G-1615 and G-1616) displayed a high antitrichinosis effect.

[The technology for manufacturing antiparasitic preparations. 6. The development of a technology for producing the anthelmintic Azinox (praziquantel) and the evaluation of its toxic and anthelmintic properties].

The paper outlines a procedure for manufacturing the anthelminthic Azinox (biltricide) using the new interfacial transfer catalyst benzyl-di-propyl (beta-hydroxyethyl)ammonium chloride. Azinox has been shown to be identical to biltricide (praziquantel) in its properties. Azinox tests on models of Opisthorchis felineus in golden hamsters and of Hymenolepis nana in albino outbred mice have indicated that the agent is not inferior to biltricide in its antitrematodal and anticestodal activities.

[The synthesis and study of the acute toxicity and anthelmintic activity of new 2-methylthiobenzimidazoles].

Several derivatives of 2-methylthiobenzimidazoles were synthesized and assayed for anthelmintic activity. Following these studies, 2-methylthio-5-(1-chloronaphthyloxy-2)-6-chlorobenzimidazole (G-1557) has been selected as a tichinellacide for detailed investigations.

[The effect of emotional stress on the efficacy of chemotherapy in experimental trichochephaliasis].

In DBA/2st mice experimentally infected with Trichocephalus muris the emotional stress caused by a cat that was placed for 2 hours twice a day during 14 days or more was found to reduce the efficiency of specific drug therapy with albendasole. At the same time there was an increase in the ED84:ED16 ratio (the effective dose of the drug which allows 84 or 16% of helminths to be eliminated), which decreased elimination probability in the whole helminth populations.

[Trials of various regimens for using medamine at different stages in the development of Nippostrongylus brasiliensis].

Experimental invasion of white outbred mice with Nippostrongylus brasiliensis show, that chemotherapeutic effectiveness of medamin is changing in various developmental stages of this helminth. Larva of the fourth phase is most sensitive to medamin; adult worm, especially in the beginning of oviposition, is less sensitive. Chemotherapeutic effect of medamin is increasing with prolongation of therapeutic period, increase of daily doses and degree of its dispersiveness.

[The clinico-immunological characteristics of hymenolepiasis].

Clinical manifestations were observed only 16 out of 61 patients aged 15-32 years who had hymenolepiasis. Despite their degree, there was impaired dexylose absorption, lower serum lysozyme activity and higher serum complement activity, depressed immunological reactivity parameters (the count of T- and B-lymphocytes, their functional activity), decreased IgA titer and increased IgE titer in the sera in all the patients observed. Six months after the effective dehelminthization, varying immunodepression still remained in all the convalescents.

[Achievements in the search for and creation of Soviet anthelmintic agents].

Basic achievements in the creation of antinematodal, anticestodal and antitrematodal agents are reviewed chronologically. It is shown that the search was performed mainly among the derivatives of benzimidazole, cyclic amidines, diphenylmethane, salicyl anilides, pyrazine isoquinolines, among natural products of avermictines and milbemicines. It is noted that nowadays there is every possibility for the treatment of mass helminthiases in the USSR.

[Characteristics of the adaptation of the dwarf tapeworm to new hosts].

Studies of the inbred lines of mice A/He, AKR and CBA infected with different strains of H. nana have shown that the helminth, when changing the host for another one of the same species but with different hereditary characters, happens to be insufficiently adapted to the new host. However it does not prevent the start of the infectious process.