Publications by authors named "Assia Duatti"
Extracellular matrix (ECM) is a major component of the tumor environment, promoting the establishment of a pro-invasive behavior. Such environment is supported by both tumor- and stromal-derived metabolites, particularly lactate. In prostate cancer (PCa), cancer-associated fibroblasts (CAFs) are major contributors of secreted lactate, able to impact on metabolic and transcriptional regulation in cancer cells.
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- Lactate, secreted by cancer-associated fibroblasts (CAF), enhances lipid metabolism in prostate cancer cells, leading to increased lipid droplet formation and promoting tumor growth.
- The study reveals a mechanism where lactate influences gene expression related to lipid metabolism and histone acetylation, creating a feedback loop between metabolites and epigenetic changes.
- Inhibiting this regulatory loop can suppress important proteins like perilipin 2 (PLIN2), reducing prostate cancer growth and metastasis, highlighting potential therapeutic targets for treatment.