Publications by authors named "Assia A Konsoulova-Kirova"
Article Synopsis
- Noncoding RNAs (ncRNAs), including microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), play crucial roles in regulating gene expression and various biological processes relevant to cancer progression.
- Research on ncRNAs has typically focused on their individual functions; however, interactions between these molecules, especially concerning tumor growth and metastasis in cancers like triple-negative breast cancer (TNBC), are not well understood.
- The study highlights emerging evidence on the dysregulation of ncRNAs in TNBC and aims to uncover their roles and regulatory networks to potentially lead to improved diagnostic and therapeutic options for this aggressive form of breast cancer.
The present study examined whether miR-17, miR-21, miR-29a, and miR-92 that are dysregulated in colon cancer (CC) can serve as potential predictive markers for relapse of disease after radical surgery and adjuvant chemotherapy. Real-time reverse transcription quantitative polymerase chain reaction was used to measure the expression levels of the miRNAs in serum samples from 37 patients with CC and 7 healthy individuals, tested as a control group. The area under the receiver operating characteristic curve (AUC) was then used to evaluate the predictive performance of the four miRNAs alone or in combination and compare it with carcinoembryonic antigen.
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