A systematic review and individual bacterial species level meta-analysis of in vitro studies on the efficacy of ceftazidime/avibactam combined with other antimicrobials against carbapenem-resistant Gram-negative bacteria.

Background: Carbapenem-resistant Gram-negative bacteria (CR-GNB) develop resistance to many antimicrobials. To effectively manage infections caused by these organisms, novel agents and/or combinations of antimicrobials are required.

Objectives: Evaluated the in vitro efficacy of ceftazidime/avibactam in combination with other antimicrobials against CR-GNB.

Availability, price, and affordability of diabetes mellitus and thyroid dysfunction medicines in South Wollo zone, Northeast Ethiopia.

Background: Diabetes mellitus and thyroid dysfunction are prevalent endocrine disorders that impose enormous burdens on patients and countries. However, access to essential medicines remains inadequate in many low-income countries. This study evaluated medications' availability, price, and affordability for these conditions.

Safety and efficacy of outpatient parenteral antimicrobial therapy: A systematic review and meta-analysis of randomized clinical trials.

Background: Outpatient parenteral antimicrobial therapy (OPAT) offers an alternative to inpatient (hospital bed-based) treatment of infections that require intravenous administration of antimicrobials. This meta-analysis aimed to summarise the evidence available from randomised controlled trials (RCTs) regarding the efficacy and safety of OPAT compared to inpatient parenteral antimicrobial therapy.

Methods: We searched the Cochrane Library, MEDLINE, Embase, PubMed, and Web of Sciences databases for RCTs comparing outpatient versus inpatient parenteral antimicrobial therapy.

What are the optimal pharmacokinetic/pharmacodynamic targets for β-lactamase inhibitors? A systematic review.

Background: Pharmacokinetic/pharmacodynamic (PK/PD) indices are widely used for the selection of optimum antibiotic doses. For β-lactam antibiotics, fT>MIC, best relates antibiotic exposure to efficacy and is widely used to guide the dosing of β-lactam/β-lactamase inhibitor (BLI) combinations, often without considering any PK/PD exposure requirements for BLIs.

Objectives: This systematic review aimed to describe the PK/PD exposure requirements of BLIs for optimal microbiological efficacy when used in combination with β-lactam antibiotics.

Effects of genotype and environment on forage yield, nutritive value and morphology of lablab (L.) sweet).

The goal of the study is to determine the effect of genotype and environment on forage yield, forage nutritive value and to determine the relation between morphology and forage yield and nutritive value of lablab. Thirteen genotypes (one local and 12 improved) were replicated 3 times in a randomized complete block trial across three locations in Ethiopian lowlands namely, Bechi, Kite and Tepi. All forage samples were analyzed for dry matter (DM), crude protein (CP), and dry matter digestibility (IVDMD) using a combination of conventional nutritional analyses and near infrared reflectance spectroscopy.

- potential supplement to 25% dorper crosses of local sheep fed a basal diet of natural pasture hay.

This research was conducted to evaluate the replacement potential of nilotica dried leaf meal for Noug Seed Cake (NSC) to supplement low quality grass hay in the diet of crossbred sheep (25% Dorper). In doing so, four treatments were set up in such a way that 0%, 33%, 67%, and 100% NSC is replaced with dried leaf of nilotica from a conventional supplement while the treatments were kept isonitrogenous. The experiment was set up in a Randomized Complete Block Design, with initials weight used as the blocking factor.

Noug Seed () Cake Substituted with Dried Mulberry () and Mixed Leaves' Meal on Growth Performances of Bonga Sheep at Teppi, Ethiopia.

This study was conducted to evaluate noug seed () cake substituted with dried mulberry and mixed leaves' meal on feed intake, body weight change, and digestibility of Bonga sheep fed on Rhodes grass hay at Teppi Agricultural Research Center, Ethiopia. The experiment was conducted using 25 yearling lambs with an average initial body weight of 20.83 ± 1.

Supplementary value of ensiled brewers spent grain used as replacement to cotton seed cake in the concentrate diet of lactating crossbred dairy cows.

The aim of this study was to investigate the effects of ensiled brewers spent grain (BSG) when used as replacement to cotton seed cake in the concentrate diet of lactating crossbred dairy cows. Eight early lactating F1 Boran X Friesian cows were used in a short term feeding trial to identify optimum level of ensiled BSG substitution of cotton seed cake (0, 33, 66, and 100%) in iso-nitrogenous diets. A 4 × 4 double Latin square design was used to analyze the data set generated from the feeding and digestibility trials.

A Chicken Production Intervention and Additional Nutrition Behavior Change Component Increased Child Growth in Ethiopia: A Cluster-Randomized Trial.

Background: Chicken production in the context of nutrition-sensitive agriculture may benefit child nutrition in low-income settings.

Objectives: This study evaluated effects of 1) a chicken production intervention [African Chicken Genetic Gains (ACGG)], and 2) the ACGG intervention with nutrition-sensitive behavior change communication (BCC) [ACGG + Agriculture to Nutrition (ATONU)], on child nutrition and health outcomes and hypothesized intermediaries.

Methods: Forty ACGG villages received 25 genetically improved chickens and basic husbandry guidance; of these, 20 ACGG + ATONU villages in addition received a nutrition-sensitive behavior change and homegardening intervention; 20 control clusters received no intervention.