Publications by authors named "Asritha Tubati"
Article Synopsis
- Vitamin B12 is essential for blood cell formation and nerve insulation, and its deficiency can lead to neurological issues despite normal blood levels, as seen in a patient with symptoms like tremor and cognitive decline.
- Researchers discovered an autoantibody against the transcobalamin receptor (CD320) that hinders vitamin B12 uptake in the brain, resulting in low levels found in cerebrospinal fluid even when blood levels appear normal.
- The study suggests this autoimmune condition can be treated with immunosuppressive therapy and high-dose vitamin B12, and highlights the importance of recognizing how B12 transport differs in various tissues, which could improve diagnosis and treatment strategies for similar neurological disorders.
Article Synopsis
- Scientists studied a group of people with multiple sclerosis (MS) to find a special antibody that could help diagnose the disease.
- They found that about 10% of these patients had a unique pattern of antibodies that could appear years before they showed any symptoms of MS.
- This discovery might help doctors identify people at high risk for MS earlier, even before the disease fully develops.
Article Synopsis
- The study focuses on the detection of anti-TRIM9 and TRIM67 autoantibodies (TRIM9/67-IgG) in patients with paraneoplastic cerebellar syndrome, aiming to determine their diagnostic value and the most effective detection methods.
- A retrospective analysis across multiple centers found that cell-based assays (CBA) were the most sensitive method for confirming the presence of TRIM9/67-IgG, identifying it in all tested cases (100%).
- The findings indicate that a significant majority of patients with TRIM9/67-IgG had subacute cerebellar syndrome and were often associated with underlying cancers, reinforcing the idea of these auto
Complement Factor I Gene Variant as a Treatable Cause of Recurrent Aseptic Neutrophilic Meningitis: A Case Report.
Neurol Neuroimmunol Neuroinflamm
September 2023
Mutations in the complement factor I () gene have previously been identified as causes of recurrent CNS inflammation. We present a case of a 26-year-old man with 18 episodes of recurrent meningitis, who had a variant in (c.859G>A,p.
View Article and Find Full Text PDFAlthough B cells are implicated in multiple sclerosis (MS) pathophysiology, a predictive or diagnostic autoantibody remains elusive. Here, the Department of Defense Serum Repository (DoDSR), a cohort of over 10 million individuals, was used to generate whole-proteome autoantibody profiles of hundreds of patients with MS (PwMS) years before and subsequently after MS onset. This analysis defines a unique cluster of PwMS that share an autoantibody signature against a common motif that has similarity with many human pathogens.
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