Comparison study on the effect of gold nanoparticles shape in the forms of star, hallow, cage, rods, and Si-Au and Fe-Au core-shell on photothermal cancer treatment.

Gold nanoparticles (GNPs) indicate potential in the development of cancer treatments as vehicles for thermal damage of cancer cells because of their photothermal heating capability. Herein, we aim to investigate the effect of GNPs geometry as photothermal transducers on cellular uptake and photothermal therapy (PTT) efficacy. For this aim, seven different shapes of anisotropic GNPs: stars, hollow, rods, cages, spheres, Fe-Au, and Si-Au core shells were synthesized and investigate the effect of shape on GNPs optical properties.

Antisense peptide nucleic acids againstftsZ andefaA genes inhibit growth and biofilm formation of Enterococcusfaecalis.

Enterococcus faecalis is one of the important causes of nosocomial infections. Nowadays, increasing prevalence of antibiotic-resistant bacteria and slow progress in recognizing new antimicrobial agents has limited the efficiency of conventional antibiotics, which cause to find novel strategies to overcome bacteria. Therefore, in this study, we aimed to assess the role of efaA gene in the biofilm formation and the role of ftsZ gene in the controlling of bacterial growth by the anti-sense PNAs(Peptide Nucleic Acid).