Publications by authors named "Asmus Tukundane"
Background: Limited data exist on the antifungal activity of daily liposomal amphotericin B with flucytosine induction regimens for cryptococcal meningitis, which are recommended in high-income countries. Liposomal amphotericin B monotherapy at 3 mg/kg previously failed to meet non-inferiority criteria compared to amphotericin B deoxycholate in its registrational clinical trial. We aimed to compare the quantitative antifungal activity and mortality between daily amphotericin B deoxycholate and daily liposomal amphotericin among persons with HIV-related cryptococcal meningitis receiving adjunctive flucytosine 100 mg/kg/day.
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- The IMPROVE trial aims to improve outcomes for adults suffering from HIV-associated cryptococcal meningitis by testing two TPT strategies for preventing tuberculosis (TB).
- The study will enroll 205 participants in Uganda, who will be randomized to receive either early inpatient or standard outpatient initiation of a one-month TB treatment regimen.
- The trial will assess the safety, feasibility, and treatment completion rates, with a focus on gathering data that could enhance TB prevention methods in high-risk populations.