Evaluation of phytochemicals and essential oils of Cupressus semprevirens in controlling cattle tick Rhipicephalus annulatus (Acari: Ixodidae).

Background: Cupressus sempervirens is one of the conifer plants, that is used as an antimicrobial, antioxidant, anthelminthic, and many other health purposes. Rhipicephalus annulatus is one of the hard tick genera affecting the production and health of domestic animals in Egypt. Extensive use of chemical acaricides in the management of ticks caused acaricide resistance, environmental contamination, residues in meat and milk, and harmful effects on non-target species.

Using gut microbiota and non-targeted metabolomics techniques to study the effect of xylitol on alleviating DSS-induced inflammatory bowel disease in mice.

Background: Inflammatory bowel disease (IBD) has become a global healthcare issue, with its incidence continuing to rise, but currently there is no complete cure. Xylitol is a widely used sweetener in various foods and beverages, but there is limited research on the effects of xylitol on IBD symptoms.

Aim: Study on the effect of oral xylitol in improving intestinal inflammation and damage in IBD mice, further explore the mechanism of xylitol in alleviating IBD symptoms using intestinal microbiota and non-targeted metabolomics techniques.

Fabrication and preliminary characterization of conductive nanofillers-enhanced polymeric hydrogels for cardiac patch applications.

The development of conducting polymeric nanocomposites patches for cardiac tissue engineering has opened new possibilities for restoring the health of infarcted heart tissues. Herein, we report the fabrication of biocompatible and relatively cost-effective poly(vinyl alcohol)/alginate-based hydrogels patches modified with different conducting nanofillers such as silver nanoparticles, polyaniline nanofibers, copper oxide nanoleaves, and graphene oxide nanosheets. The impact of the different nanofiller materials on the molecular structure, charge transport mechanism and mechanical characteristics of the designed nanocomposites patches was investigated.

Long-term effects of dupilumab on chronic rhinosinusitis with nasal polyps: A step towards clinical remission.

Background And Objectives: Clinical remission, defined as the absence of disease activity and symptoms, is an emerging goal in the management of chronic rhinosinusitis with nasal polyps (CRSwNP). This study aimed to evaluate the long-term effects of dupilumab on patients with CRSwNP, with or without asthma, and explore the potential for achieving clinical remission.

Methods: A two-year prospective study was conducted on 109 patients with CRSwNP, with or without asthma, who were eligible for dupilumab as an add-on therapy.

Analysis of four long non-coding RNAs for hepatocellular carcinoma screening and prognosis by the aid of machine learning techniques.

Hepatocellular carcinoma (HCC) represents a significant health burden in Egypt, largely attributable to the endemic prevalence of hepatitis B and C viruses. Early identification of HCC remains a challenge due to the lack of widespread screening among at-risk populations. The objective of this study was to assess the utility of machine learning in predicting HCC by analyzing the combined expression of lncRNAs and conventional laboratory biomarkers.

Cuticular composition: An alternative taxonomic approach to differentiate between Argas arboreus and Argas persicus ticks (Acari: Argasidae).

Argas arboreus and A. persicus are blood sucking ectoparasites on domestic birds in Egypt. They cause anemia in birds, in addition to transmitting a variety of pathogens that leads to economical loss in the poultry industry.

Palmitoleic and oleic fatty acids as biomarkers for coronary heart disease: A predictive model.

Background: saturated and unsaturated fatty acid showed a significant link with coronary artery health and disease.

Objective: This study aimed to compare plasma levels of unsaturated fatty acids (UFAs) between individuals with coronary heart disease (CHD) and those without. It also investigated the association between specific UFA ratios and the presence or severity of acute coronary syndrome (ACS).

In-vitro and in-vivo assessment of the bactericidal potential of peracetic acid and hydrogen peroxide disinfectants against A. hydrophila infection in Nile tilapia and their effect on water quality indices and fish stress biomarkers.

This study aimed to assess the in vitro and in vivo disinfectant potential of peracetic acid (PAA) (1 mg/L) and hydrogen peroxide (HO) (20 mg/L) on the physicochemical and microbiological water quality parameters of fish aquaria, the microbial density of Nile tilapia muscular tissue, fish hepatic cortisol levels, and antioxidant biomarkers. In vitro, PAA and HO reduced A. hydrophila colony viability by 5 log units after 30 and 5 min of contact time, respectively.

Effect of Dupilumab on Radiological Remission in Patients with Chronic Rhinosinusitis with Nasal Polyp: A One Step Forward Toward Clinical Remission.

Background And Objectives:  While achieving complete radiological improvement in patients with nasal polyps is often observed following surgical resection, the impact of biologic therapy, specifically dupilumab, on polyp size is an area of great interest. The objective of this study was to assess the effect of dupilumab in patients with chronic rhinosinusitis with nasal polyps (CRSwNP) by assessing nasal polyps using the computed tomography (CT) staging system, Lund-Mackay score (LMS).

Methods:  A two-year prospective cohort study was conducted on 29 patients diagnosed with CRSwNP and asthma and eligible for dupilumab as an add-on therapy.

Advanced interpretable diagnosis of Alzheimer's disease using SECNN-RF framework with explainable AI.

Early detection of Alzheimer's disease (AD) is vital for effective treatment, as interventions are most successful in the disease's early stages. Combining Magnetic Resonance Imaging (MRI) with artificial intelligence (AI) offers significant potential for enhancing AD diagnosis. However, traditional AI models often lack transparency in their decision-making processes.

Evaluation of the mechanical properties and degradation behavior of chitosan-PVA-graphene oxide nanocomposite scaffolds in vitro.

Objectives: Chitosan (CTS) has been a popular option for scaffold fabrication because of its biocompatibility, biodegradability, antimicrobial and nonimmunogenic effects. However, it is of limited function, due to its low mechanical strength and its solubility in acidified media. These limitations could be overcome by its blending with PVA and incorporation with bioactive materials to improve its mechanical properties and tissue regeneration capability.

Knowledge, Perceptions and Attitude of Researchers Towards Using ChatGPT in Research.

Introduction: ChatGPT, a recently released chatbot from OpenAI, has found applications in various aspects of life, including academic research. This study investigated the knowledge, perceptions, and attitudes of researchers towards using ChatGPT and other chatbots in academic research.

Methods: A pre-designed, self-administered survey using Google Forms was employed to conduct the study.

Histopathological effects of the fruit extract of Citrullus colocynthis on the ovary of the tick Hyalomma dromedarii.

Hyalomma dromedarii is the predominant tick species parasitizing camels in Egypt which leads to mortalities in young animals that result in economic losses. It can transmit a lot of pathogens to animals and humans, such as the Crimean-Congo hemorrhagic fever virus, the Dhori virus, Kadam virus, Theileria annulata and spotted fever rickettsia. The continuous use of chemical acaricides has negative impact on the environment and almost led to acaricidal resistance, and hence the plant extracts represent alternative methods for controlling ticks.

Analysis of Marrubiin in L. Extract Using Advanced HPTLC: Chemical Profiling, Acetylcholinesterase Inhibitory Activity, and Molecular Docking.

The main purpose of this work is to investigate the phytochemical composition of L. non-polar fraction. GC/MS analysis was used to evaluate the plant extract's saponifiable and unsaponifiable matter.

Factors influencing poor response to type 2 targeted therapies in severe asthma: a retrospective cohort study.

Background: A significant breakthrough has been made in treating severe asthma, with the recognition of various asthma phenotypes and an updated management guideline. Type 2 targeted therapies, such as benralizumab and omalizumab; have been identified as an effective treatment for severe asthma, improving patient response, lung function tests and asthma symptom control. This study aimed to evaluate factors contributing to poor response to therapy.

Interleukin-4 (C590T) Gene Polymorphism in Association with Asthma Severity.

Background: A significant link between T allele of the (C590T) gene and developing asthma in some populations was reported. However, no study discussed the link between (C590T) gene polymorphism and asthma severity groups (mild and severe). This study investigated the link between gene variation and asthma severity.

Monocyte to eosinophil ratio as a diagnostic biomarker for overlap syndrome and predictor of disease exacerbation.

Chronic Obstructive Pulmonary Disease (COPD) is one of the most common pulmonary diseases. The concomitant association of Obstructive Sleep Apnea (OSA) and COPD is known as the Overlap Syndrome (OS). This study aimed to identify markers for predicting OS, among routine laboratory tests, including differential blood counts.

Even one dose of tocilizumab could hinder bad prognosis of cytokines storm in COVID-19 patients.

Severe COVID-19 pneumonia is a principal cause of death due to cascade of hyper inflammatory condition that leading to lung damage. Therefore, an effective therapy to countercurrent the surge of uncontrolled inflammation is mandatory to propose. Anti-interlukin-6 receptor antagonist monoclonal therapy, tocilizumab (TCZ) showed potential results in COVID-19 patients.

Controlling Argas arboreus and A. persicus (Acari: Argasidae) by Adiantum capillus-veneris L. extracts with phytochemical analysis.

Argas species are parasites associated mostly with birds. Their infestations of the host may cause blood loss, resulting in anemia and finally death. Egypt loses millions of tons annually from birds because of these parasites.

YKL-40 in serum: a promising biomarker of juvenile SLE and strongly correlated with disease duration.

Background: The biological function of YKL-40 is not well determined in different inflammatory and autoimmune diseases; however, some data highlighted its possible connection with disease activity.

Aim: We investigated the diagnostic utility of serum YKL-40 in patients with SLE and examined its correlation with disease activity. Additionally, we examined any differences in serum YKL-40 levels between juvenile and adult SLE patients.

Modified electrode decorated with silver as a novel non-enzymatic sensor for the determination of ammonium in water.

Ammonium is an essential component of the nitrogen cycle, which is essential for nitrogen cycling in ecosystems. On the other hand, ammonium pollution in water poses a great threat to the ecosystem and human health. Accurate and timely determination of ammonium content is of great importance for environmental management and ensuring the safety of water supply.

Omalizumab Transitions in Severe Asthma: Factors Influencing Switching Decisions and Timing for Optimal Response.

Objective: The objective of this study was to assess the effectiveness of switching from omalizumab to another biologic therapy for patients with severe asthma and evaluate factors that influenced the decision to switch and determined the optimal time for a good biologic response.

Subjects And Methods: A retrospective study of severe asthma patients was conducted at Al-Rashed Allergy Center, a tertiary center in Kuwait. After meeting the eligibility criteria, patients were divided into two comparative groups: those continuing with omalizumab and those who started with omalizumab but switched to another biologic.

Gut microbiota and acute kidney injury: immunological crosstalk link.

The gut microbiota, often called the "forgotten organ," plays a crucial role in bidirectional communication with the host for optimal physiological function. This communication helps regulate the host's immunity and metabolism positively and negatively. Many factors influence microbiota homeostasis and subsequently lead to an immune system imbalance.