Serum and salivary adipsin levels and its association with insulin resistance in acne vulgaris patients.

Background: There is scarcity in literature about the reliability of salivary markers in acne vulgaris.

Aims: The aims were to evaluate the insulin resistance (IR) and adipsin levels in serum and saliva in a sample of acne vulgaris patients; and to correlate IR and adipsin levels with the disease severity.

Methods: This prospective case-control study included 60 acne vulgaris patients (patients Group), in addition, 60 apparently healthy individuals (control group).

Methotrexate Mechanism of Action in Plaque Psoriasis: Something New in the Old View.

Background: Despite the era of biologic therapy in the management of psoriasis, methotrexate, the traditional backbone of psoriasis treatment, does not stop surprising us with what it can offer.

Objective: In this study, we aimed to evaluate the peripheral expression and the serum levels of TWEAK in patients with psoriasis vulgaris before and after receiving methotrexate treatment.

Methods: The study included 58 patients with moderate to severe psoriasis vulgaris, and 90 apparently healthy individuals as a control group.

Unraveling the relation between vitiligo, Interleukin 17, and serum amyloid A.

Background: There is debate concerning the precise etiopathogenesis of vitiligo. According to certain theories, a series of inflammatory responses that mediate the loss of melanocytes are caused by both cellular and humoral immune responses. It has also been demonstrated that Interleukin 17 (IL-17) promotes melanocyte death and inhibits melanogenesis through different mechanisms.

HMGB1-RAGE-moesin axis may be indicted for acne vulgaris.

Background: High-mobility group box 1 (HMGB1)-receptor for advanced glycation end (RAGE)-moesin axis could be implicated in induction of inflammation. However, there is a scarcity in literature discussing the role of this axis in inflammatory skin disorders.

Aims: The aim of the present study was to evaluate the serum levels of HMGB1 and moesin in patients with inflammatory acne vulgaris.

Inflammatory markers in acne vulgaris: Saliva as a novel diagnostic fluid.

Background: Despite the wide use of saliva-based measurements in inflammatory, autoimmune and neoplastic conditions, its use in dermatology is still limited.

Aims: The aims of this study were to assess the serum and salivary levels of interleukin-1 beta (IL-1β) and C-reactive protein (CRP) in patients with acne vulgaris.

Patients/methods: The study included 84 moderate-to-severe acne vulgaris patients, in addition to 105 healthy control subjects.

Serum Zinc and Inflammatory Cytokines in Vitiligo.

The relation between zinc and the cytokines involved in vitiligo pathogenesis has not been studied well. We aimed to investigate the serum levels of zinc in patients with vitiligo and to assess their relation to serum interleukins (IL)-4, IL-6, and IL-17. The study included 50 patients with active vitiligo and 100 age-, sex-, and BMI-matched healthy volunteers as a control group.

Factors affecting vitiligo response to treatment: do MiRNA 196a2C/T gene polymorphism and serum tyrosinase levels have any role?

Background: Factors contributing to the pathogenesis of vitiligo and factors affecting its response to treatment are still a major area of debate.

Aim Of The Work: The study aimed to assess the serum levels of tyrosinase and Micro-RNAs (miRNAs) gene polymorphism in a sample of Egyptian vitiligo patients, and to determine factors affecting the response of vitiligo to treatment.

Subjects And Methods: This prospective case-control interventional study included 212 non-segmental vitiligo patients and 96 control subjects.

Insulin resistance and idiopathic infertility: A potential possible link.

Among various health issues, infertility has been always considered as one of the major health problems. Idiopathic infertility is still a matter of debate since the underlying mechanisms stay obscure. Idiopathic infertility is related to expanded chance of metabolic syndrome components, obesity and increased risk of cardiovascular diseases.