Publications by authors named "Asmaa A A Ali"
Ital J Pediatr
September 2020
Article Synopsis
- - Hemophilia A (HA) is a genetic bleeding disorder caused by a deficiency of factor VIII (FVIII), with a key complication being the development of inhibitors against FVIII, influenced by mutations like intron 22 inversion (Inv22).
- - A study involving 72 severe and 48 moderate HA patients in Egypt found that 23% had the Inv22 mutation, with a significantly higher incidence in severe cases (33%) compared to moderate ones (6%).
- - The presence of the Inv22 mutation greatly increases the risk of developing inhibitors, with affected patients experiencing a fourfold higher likelihood of inhibitor development compared to those without the mutation.
