Challenges in Preanalytical Phase of Laboratory Medicine: Rate of Blood Sample Nonconformity in a Tertiary Care Hospital.

Objective: To evaluate the major causes of preanalytical errors in medical laboratory of a tertiary care hospital.

Methods: It was a retrospective study in which we analyzed the sample rejection data of hematology and chemical pathology sections from January to December 2018. Number of rejected samples, reason for rejection and type of test ordered on monthly basis were recorded on a platform.

Familial Clustering of Antiphospholipid Syndrome.

Antiphospholipid syndrome (APS) is a systemic autoimmune disease characterised by thrombosis (venous or arterial) and/or pregnancy-related complications. There is very scanty literature available regarding familial occurrence of APS worldwide and to the best of our knowledge, this important aspect has never been previously reported from Pakistan. We are presenting three patients of a Pakistani family who presented with thrombotic and pregnancy-related complications.

Macrophage Activation Syndrome Associated With Adult Onset Still's Disease.

Macrophage activation syndrome (MAS) is a potentially lethal complication of chronic rheumatological conditions like ankylosing spondylitis, rheumatoid arthritis, and adult-onset Still's disease (AOSD). It is a multisystem inflammatory syndrome caused by immense cytokine release from activated lymphocytes and macrophages. We give an account of the incidence of a twenty years old Asian girl suffering from non-remitting fever and an evanescent rash for last ten weeks.