Publications by authors named "Asma Almaidhan"
Article Synopsis
- The calvaria, or upper part of the skull, develops from mesenchyme around the brain, with specific regions (like supra-orbital mesenchyme) promoting bone growth while others (early migrating mesenchyme) do not.
- Researchers discovered Lmx1b, a gene that acts as an anti-osteogenic factor in early migrating mesenchyme, helping to differentiate areas with varying capacities for bone development.
- Altering the expression of Lmx1b can lead to abnormal bone growth and conditions like craniosynostosis, highlighting its crucial role in the proper formation and organization of the skull.
Comparative Analysis of Three-Dimensional Nasal Shape of Casts from Patients With Unilateral Cleft Lip and Palate Treated at Two Institutions Following Rotation Advancement Only (Iowa) or Nasoalveolar Molding and Rotation Advancement in Conjunction With Primary Rhinoplasty (New York).
Cleft Palate Craniofac J
November 2018
Objectives: To compare 3-dimensional nasal symmetry in patients with UCLP who had either rotation advancement alone or nasoalveolar molding (NAM) followed by rotation advancement in conjunction with primary nasal repair.
Design: Pilot retrospective cohort study.
Materials And Methods: Nasal casts of 23 patients with UCLP from 2 institutions were analyzed; 12 in the rotation advancement only group (Iowa) and 11 in the NAM, rotation advancement with primary nasal repair group (New York).
Development of the face is regulated by a large number of genes that are expressed in temporally and spatially specific patterns. While significant progress has been made on characterizing the genes that operate in the oral region of the face, those regulating development of the aboral (lateral) region remain largely unknown. Recently, we discovered that transcription factors LIM homeobox (LHX) 6 and LHX8, which are key regulators of oral development, repressed the expression of the genes encoding forkhead box transcription factors, Foxp1 and Foxp2, in the oral region.
View Article and Find Full Text PDFArticle Synopsis
- LDB1 is crucial for craniofacial development, specifically in forming the secondary palate, as shown in tissue-specific mutant mouse models.
- Mutant embryos with LDB1 deletion exhibited cleft palates and abnormal palatal shelf morphology due to defective elevation above the tongue and altered cell proliferation.
- The study highlights the role of LDB1 in regulating key developmental genes like Wnt5a, Pax9, and Osr2 necessary for normal palate morphogenesis.
Aim: To evaluate and compare the perceptions of Saudi dentists and lay people to altered smile features.
Methods: Thirty-six digital smile photographs with altered features were used. Altered features included the following: crown length, width, gingival level of the lateral incisors, gingival display, midline diastema, and upper midline shift.